{"id":962,"date":"2023-12-20T11:28:38","date_gmt":"2023-12-20T03:28:38","guid":{"rendered":"http:\/\/baijianyy.cn\/?p=962"},"modified":"2023-12-20T11:28:38","modified_gmt":"2023-12-20T03:28:38","slug":"%e8%90%8d%e4%b9%a1%e5%b8%82%e8%8a%a6%e6%ba%aa%e5%8e%bf%e4%bb%80%e4%b9%88%e5%8f%ab%e5%81%9a%e9%ab%98%e5%8d%b1%e6%80%a7%e7%94%9f%e6%b4%bbhiv%e6%9a%b4%e9%9c%b2%e5%89%8d%e9%a2%84%e9%98%b2%e8%8d%af","status":"publish","type":"post","link":"http:\/\/baijianyy.cn\/?p=962","title":{"rendered":"\u840d\u4e61\u5e02\u82a6\u6eaa\u53bf\u4ec0\u4e48\u53eb\u505a\u9ad8\u5371\u6027\u751f\u6d3b?HIV\u66b4\u9732\u524d\u9884\u9632\u836f\u7269\u5b89\u5168\u5417\uff1f\u4f60\u5173\u5fc3\u7684\u4e03\u4e2a\u5b89\u5168\u6027\u95ee\u9898"},"content":{"rendered":"<p>\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" 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href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u5168\u56fd\u4e24\u5c0f\u65f6\u6025\u9001\uff0c\u836f\u5e97\u76f4\u53d1\uff0c\u4e13\u4eba\u4e13\u9001<\/p>\n<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85\" target=\"_blank\" 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PrEP\uff09\u662fHIV\u7efc\u5408\u9884\u9632\u7b56\u7565\u4e2d\u91cd\u8981\u7684\u9884\u9632\u65b9\u6cd5\u4e4b\u4e00\uff0c\u672a\u611f\u67d3\u8005\u670d\u7528HIV\u6cbb\u7597\u836f\u7269\uff0c\u5728\u4f53\u5185\u8fbe\u5230\u5177\u4fdd\u62a4\u6027\u7684\u836f\u7269\u6d53\u5ea6\uff0c\u4ee5\u964d\u4f4e\u5176\u63a5\u89e6\u75c5\u6bd2\u540e\u7684\u611f\u67d3\u98ce\u9669\u3002<\/p>\n<p>PrEP\u9002\u7528\u4e8e<strong>\u672a\u611f\u67d3HIV<\/strong>\u7684HIV\u611f\u67d3\u8005\u7684\u914d\u5076\u3001\u4e0eHIV\u9ad8\u98ce\u9669\u7537\u6027\u53d1\u751f\u6027\u884c\u4e3a\u7684\u7537\u6027\u548c\u8de8\u6027\u522b\u5973\u6027\uff0c\u4ee5\u53ca\u6ce8\u5c04\u6bd2\u54c1\u4eba\u7fa4\u7b49\u3002<\/p>\n<p>\u5177\u4f53\u9002\u7528\u4eba\u7fa4\u53ca\u65b9\u6848\u63a8\u8350\u89c1\u4e0b\u8868\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-965\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/1-12.jpg\" alt=\"\" width=\"905\" height=\"1005\" srcset=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/1-12.jpg 905w, http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/1-12-768x853.jpg 768w\" sizes=\"(max-width: 905px) 100vw, 905px\" \/><\/p>\n<p>\u76ee\u524d\u5bcc\u9a6c\u9178\u66ff\u8bfa\u798f\u97e6\u4e8c\u5421\u544b\u916f\/\u6069\u66f2\u4ed6\u6ee8\uff08TDF\/FTC\uff09\u662f\u6211\u56fd\u552f\u4e00\u83b7\u6279HIV PrEP\u9002\u5e94\u8bc1\u7684\u836f\u7269\uff0c\u4e5f\u662fWHO\u9996\u4e2a\u63a8\u8350\u7528\u4e8eHIV PrEP\u7684\u53e3\u670d\u836f\u7269\uff0c\u5df2\u5728\u5168\u7403\uff1e50\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u83b7\u6279\u4f7f\u7528\u3002<\/p>\n<p>\u5e94\u7528\u5341\u4f59\u5e74\u6765\uff0c\u5927\u91cf\u8bc1\u636e\u663e\u793a\uff0cPrEP\u5728HIV\u66b4\u9732\u9ad8\u98ce\u9669\u4eba\u7fa4\u4e2d\u53ef\u964d\u4f4e\u81f3\u5c1190%\u7684\u611f\u67d3\u98ce\u9669\uff0c\u7f8e\u56fd\u3001\u80af\u5c3c\u4e9a\u3001\u4e4c\u5e72\u8fbe\u7b49\u591a\u4e2a\u56fd\u5bb6\u7684\u6a2a\u65ad\u9762\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u4e5f\u90fd\u53cd\u6620\u51faPrEP\u63a8\u5e7f\u540eHIV\u65b0\u53d1\u611f\u67d3\u75c5\u4f8b\u6570\u663e\u8457\u4e0b\u964d\u3002<\/p>\n<p>\u6ce8\u610f\uff1a\u5b9e\u65bdPrEP\u524d\u5fc5\u987b\u8fdb\u884cHIV\u68c0\u6d4b\uff0c\u786e\u4fdd\u7528\u836f\u8005\u6ca1\u6709\u611f\u67d3HIV\u3002<\/p>\n<p>\u5bf9\u5df2\u7ecf\u611f\u67d3\u4f46\u4ece\u672a\u88ab\u8bca\u65ad\u51fa\u7684HIV\u9633\u6027\u8005\u8fdb\u884cPrEP\u53ef\u80fd\u4f1a\u5bfc\u81f4\u8010\u836f\u53d1\u751f\uff0c\u5bf9\u5176\u540e\u7eed\u6cbb\u7597\u4ea7\u751f\u4e25\u91cd\u7684\u4e0d\u826f\u540e\u679c\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u57fa\u7ebf\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u8fd8\u9700\u6392\u9664\u670d\u7528TDF\/FTC\u7684\u7981\u5fcc\u8bc1\u548c\u76f8\u5173\u60c5\u51b5\u3002<\/p>\n<p>\u5b89\u5168\u6027\u662f\u5f71\u54cd\u9ad8\u98ce\u9669\u4eba\u7fa4PrEP\u7684\u610f\u613f\u548c\u7528\u836f\u4f9d\u4ece\u6027\u7684\u4e3b\u8981\u56e0\u7d20\u4e4b\u4e00\u3002TDF\/FTC\u4f5c\u4e3aPrEP\u836f\u7269\u5b89\u5168\u6027\u5982\u4f55\uff1f\u672c\u6587\u5c06\u4e3a\u60a8\u89e3\u7b54\u3002<\/p>\n<p>TDF\/FTC\u7528\u4e8ePrEP\u7684\u6574\u4f53\u5b89\u5168\u6027\u826f\u597d<\/p>\n<p>TDF\/FTC\u4f5c\u4e3a<a href=\"http:\/\/baijianyy.cn\/?tag=prep%e7%94%a8%e8%8d%af\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201cPrEP\u7528\u836f\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">PrEP\u7528\u836f<\/a>\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u5728PrEP \u521a\u5f00\u59cb\u76844\u5468\u5185\uff0c\u6709\u5c11\u90e8\u5206\u4e2a\u4f53\u670d\u836f\u540e\u53ef\u80fd\u4f1a\u51fa\u73b0\u8f7b\u5ea6\u7684\u6076\u5fc3\u3001\u5934\u75db\u3001\u4f53\u91cd\u51cf\u8f7b\u6216\u5176\u4ed6\u75c7\u72b6\uff0c\u4f46\u5927\u591a\u6570\u75c7\u72b6\u5728\u4e4b\u540e4\u5468\u5185\u4f1a\u6d88\u5931\u6216\u7f13\u89e3\u3002<\/p>\n<p>\u5e94\u5bf9\uff1aPrEP \u836f\u7269\u7684\u4e0d\u826f\u53cd\u5e94\u5e76\u4e0d\u5e38\u89c1\uff0c\u901a\u5e38\u4f1a\u5728\u670d\u7528\u836f\u7269\u540e\u7684\u7b2c\u4e00\u4e2a\u6708\u5185\u5f97\u5230\u7f13\u89e3\uff0c\u533b\u751f\u6216\u516c\u5171\u536b\u751f\u4eba\u5458\u53ef\u4ee5\u63a8\u8350PrEP \u53c2\u4e0e\u8005\u4f7f\u7528\u975e\u5904\u65b9\u836f\u6765\u6cbb\u7597\u5934\u75db\u3001\u6076\u5fc3\u548c\u80a0\u80c3\u6c14\u80c0\u7b49\u75c7\u72b6\u3002<\/p>\n<p>TDF\/FTC\u7528\u4e8ePrEP\u5bf9\u80be\u529f\u80fd\u5f71\u54cd\u8f83\u5c0f<\/p>\n<p>\u603b\u4f53\u6765\u770b\uff0cTDF\u7528\u836f\u540e\u53ef\u81f4\u4e00\u8fc7\u6027\u7684\u8f7b\u5ea6\u808c\u9150\u6e05\u9664\u7387\u4e0b\u964d\uff0c\u505c\u836f\u540e\u53ef\u6062\u590d\u3002<\/p>\n<p>iPrEx\u7814\u7a76\u7684\u7ed3\u679c\u663e\u793a\uff0cPrEP\u7ec4\u53c2\u4e0e\u8005\u7684\u808c\u9150\u6e05\u9664\u7387\uff08CrCl\uff09\u6709\u5c0f\u5e45\u7684\u4e0b\u964d\uff0c\u8fd9\u79cd\u4e0b\u964d\u4ece\u7b2c4\u5468\u5f00\u59cb\u51fa\u73b0\uff0c\u6301\u7eed\u5230\u505c\u836f\uff0c\u5728\u505c\u836f\u540e\u9010\u6e10\u9006\u8f6c\u3002\u7814\u7a76\u4eba\u5458\u6ca1\u6709\u53d1\u73b0\u8fd9\u79cd\u53d8\u5316\u6709\u79cd\u65cf\u3001\u5e74\u9f84\u548c\u9ad8\u8840\u538b\u75c5\u53f2\u7684\u5dee\u5f02\uff0c\u4e0d\u8fc7\u4f1a\u53d7\u5230\u975e\u753e\u4f53\u6297\u708e\u836f\u7269\u4f7f\u7528\u7684\u5f71\u54cd\u3002<\/p>\n<p>\u4f30\u8ba1\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\uff08eGFR\uff09\u7684\u53d8\u5316\u4e0eCrCl\u7c7b\u4f3c\uff0cPartners PrEP\u7814\u7a76[5]\u548cANRS-IPERGAY\u8bd5\u9a8c\u6570\u636e\u5206\u6790\u7684\u7ed3\u679c\u5747\u663e\u793a\uff0cTDF\/FTC\u7528\u4e8ePrEP\u80be\u810f\u5b89\u5168\u6027\u826f\u597d\uff0cPrEP\u671f\u95f4eGFR\u6709\u5c0f\u5e45\u7684\u53d8\u5316\uff0c\u4e14\u80fd\u591f\u5728\u505c\u836f\u540e\u6062\u590d\u3002<\/p>\n<p>\u5728HIV\/AIDS\u5e72\u9884\u9752\u5c11\u5e74\u836f\u7269\u8bd5\u9a8c\u7f51\u7edc\uff08ATN\uff09\u961f\u5217110\uff0818-22\u5c81\uff09\u548c113\uff0815-17\u5c81\uff09\u4e2d\uff0c\u53ea\u6709ANT 110\u4e2d\u7684\u4e00\u4f8b\u62a5\u544a\u4e86\u808c\u9150\u6c34\u5e73\u7684\u4e00\u7ea7\u5347\u9ad8\uff0c\u4e14\u5728\u540e\u7eed\u7684\u968f\u8bbf\u4e2d\u6062\u590d\u4e86\u6b63\u5e38\u3002<\/p>\n<p>\u5e94\u5bf9\uff1a\u5728HIV\u611f\u67d3\u7684\u6cbb\u7597\u6307\u5357\u4e2d\uff0c\u5bf9\u4f30\u8ba1\u808c\u9150\u6e05\u9664\u7387\uff08eCrCl\uff09\uff1c60 mL\/min \u7684\u53d7\u8bd5\u8005\u4e0d\u5efa\u8bae\u4f7f\u7528TDF 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PrEP\u7814\u7a76\u548ciPrEx\u7814\u7a76\u5747\u53d1\u73b0\u4e86\u9aa8\u5bc6\u5ea6\u7684\u4e0b\u964d\u3002Partners 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