{"id":4080,"date":"2024-11-01T10:51:28","date_gmt":"2024-11-01T02:51:28","guid":{"rendered":"http:\/\/baijianyy.cn\/?p=4080"},"modified":"2024-11-01T10:51:28","modified_gmt":"2024-11-01T02:51:28","slug":"%e5%a4%a7%e5%ba%86%e5%b8%82-%e5%a4%a7%e5%90%8c%e5%8c%ba-%e9%98%bb%e6%96%ad%e8%8d%af%e4%bb%80%e4%b9%88%e7%89%8c%e5%ad%90%e7%9a%84%e5%a5%bd-%e4%bd%a0%e4%ba%86%e8%a7%a3%e9%98%bb%e6%ad%a2hiv%e8%bf%9b","status":"publish","type":"post","link":"http:\/\/baijianyy.cn\/?p=4080","title":{"rendered":"\u5927\u5e86\u5e02 \u5927\u540c\u533a \u963b\u65ad\u836f\u4ec0\u4e48\u724c\u5b50\u7684\u597d \u4f60\u4e86\u89e3\u963b\u6b62HIV\u8fdb\u5165\u7ec6\u80de\u7684\u836f\u7269\u5417\uff1f"},"content":{"rendered":"<p>\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54c1\u9500\u552e\u673a\u6784\uff1f<br 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class=\"tag_link\">\u9ad8\u5371\u884c\u4e3a<\/a>\u540e\u591a\u4e45\u68c0\u6d4b\uff1f\u9ad8\u5371\u6027\u884c\u4e3a\u4e00\u6b21\u8981\u5403\u963b\u65ad\u836f\u5417\uff1f\u53d1\u751f\u9ad8\u5371\u6027\u884c\u4e3a\u540e\u600e\u4e48\u529e\uff1f\u9ad8\u5371\u884c\u4e3a\u591a\u5c11\u5929\u540e\u53ef\u4ee5\u5f7b\u5e95\u6392\u9664\uff1f\u7b49\u7b49\u95ee\u9898\uff0c\u53ef\u4ee5\u5728\u4e92\u8054\u7f51\u533b\u9662\u514d\u8d39\u54a8\u8be2\u4e13\u4e1a\u611f\u67d3\u79d1\u533b\u5e08\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-3911 aligncenter\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2024\/05\/mmexport1702183130138-1-1.gif\" alt=\"\" width=\"300\" height=\"300\" \/><\/p>\n<p>\u963b\u65ad\u836f\u4ec0\u4e48\u724c\u5b50\u7684\u597d \u6b64\u95ee\u9898\u8bf7\u626b\u4e0a\u9762\u7684\u4e8c\u7ef4\u7801\u5173\u6ce8\u4e92\u8054\u7f51\u533b\u9662\uff0c\u4e3a\u60a8\u89e3\u7b54\uff01<\/p>\n<p>\u81ea\u613f\u54a8\u8be2\u68c0\u6d4b\u673a\u6784\uff1a\u5927\u5e86\u5e02\u5927\u540c\u533a\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3<\/p>\n<p>\u5730\u5740\uff1a\u5927\u540c\u533a\u540c\u57ce\u8def4\u53f7<\/p>\n<p>HIV\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u7684\u7b56\u7565\u662f\u819c\u878d\u5408\uff0cHIV\u5305\u819c\u7cd6\u86cb\u767d\u8d77\u7740\u878d\u5408\u7684\u4f5c\u7528\u3002\u9996\u5148HIV\u5305\u819c\u86cb\u767d\u9644\u7740\u5230\u7ec6\u80de\u4e0a\uff0c\u518d\u4e0eCD4\u53d7\u4f53\u548c\u8f85\u52a9\u53d7\u4f53\uff08\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53CCR5\u6216CXCR4\uff09\u7ed3\u5408\uff0c\u5e76\u8bf1\u5bfc\u75c5\u6bd2\u548c\u7ec6\u80de\u819c\u878d\u5408\u3002\u6b64\u65f6\uff0c\u5305\u819c\u86cb\u767d\u4f1a\u53d1\u751f\u5927\u7684\u6784\u8c61\u53d8\u5316\u4ee5\u9a71\u52a8\u819c\u878d\u5408\uff0c\u6700\u540e\u75c5\u6bd2\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u3002\u5c3d\u7ba1\u5305\u819c\u86cb\u767d\u6bd4\u90a3\u4e9b\u75c5\u6bd2\u7f16\u7801\u7684\u9176\uff08\u5982\u9006\u8f6c\u5f55\u9176\u6216\u86cb\u767d\u9176\uff09\u5177\u6709\u66f4\u5927\u7684\u591a\u6837\u6027\uff0c\u4f46\u5305\u819c\u86cb\u767d\u4fc3\u8fdb\u878d\u5408\u7684\u6784\u8c61\u53d8\u5316\u66b4\u9732\u4e86\u4e00\u4e9b\u9ad8\u5ea6\u4fdd\u5b88\u3001\u5173\u952e\u529f\u80fd\u7684\u533a\u57df\uff0c\u6210\u4e3a\u5f00\u53d1\u8fdb\u5165\u6291\u5236\u5242\u7684\u9776\u6807\u3002HIV\u8fdb\u5165\u6291\u5236\u5242\u65e0\u9700\u7a7f\u8fc7\u7ec6\u80de\u819c\u5373\u53ef\u5230\u8fbe\u5176\u9776\u70b9\uff0c\u56e0\u6b64\uff0c\u5b83\u662f\u66f4\u6709\u53ef\u80fd\u6210\u4e3a\u5177\u6709\u9ad8\u7279\u5f02\u6027\uff0c\u4f46\u526f\u4f5c\u7528\u4f4e\u7684\u4e00\u7c7b\u6291\u5236\u5242\u3002<img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-4081\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2024\/11\/\u5fae\u4fe1\u56fe\u7247_20241101105016.png\" alt=\"\" width=\"299\" height=\"286\" \/><\/p>\n<p><strong>\u878d\u5408\u6291\u5236\u5242<\/strong><\/p>\n<p>HIV gp41\u516d\u87ba\u65cb\u675f\u7ed3\u6784\u7684\u5f62\u6210\u5bf9\u75c5\u6bd2\u611f\u67d3\u6027\u81f3\u5173\u91cd\u8981\uff0c\u5e76\u4e14\u5df2\u7ecf\u5f00\u53d1\u4e86\u8bb8\u591a\u57fa\u4e8e\u80bd\u7684\u6291\u5236\u5242\u6765\u963b\u65ad\u8be5\u6b65\u9aa4\u3002\u6e90\u81eaHR1\u6216HR2\u7684\u5408\u6210\u80bd\u65e8\u5728\u7ed3\u5408gp41\u7684\u878d\u5408\u4e2d\u95f4\u4f53\u5e76\u9632\u6b62\u516d\u87ba\u65cb\u675f\u7684\u5f62\u6210<sup>[1]<\/sup>\u3002<strong>T20\/Enfuvirtide<\/strong><strong>\uff0c\u4e00\u79cd\u6e90\u81ea<\/strong><strong>gp41<\/strong><strong>\u7684<\/strong><strong>36<\/strong><strong>\u6b8b\u57fa\u80bd\uff0c\u662f<\/strong><strong>USFDA<\/strong><strong>\u6279\u51c6\u7684\u7b2c\u4e00\u4e2a\u878d\u5408\u6291\u5236\u5242<\/strong><sup>[2]<\/sup>\u3002\u5c3d\u7ba1\u53d6\u5f97\u4e86\u521d\u6b65\u6210\u529f\uff0c\u4f46Enfuvirtide\u5fc5\u987b\u5728\u4f4e\u6e29\u4e0b\u50a8\u5b58\u3001\u65b0\u9c9c\u914d\u7f6e\u5e76\u6bcf\u5929\u76ae\u4e0b\u6ce8\u5c04\u4e24\u6b21\uff0c\u64cd\u4f5c\u6210\u672c\u6bd4\u8f83\u5927\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63d0\u9ad8\u57fa\u4e8eHR2\u80bd\u7684\u6548\u529b\uff0c\u76ee\u524d\u5df2\u7ecf\u63a2\u7d22\u4e86\u4e0d\u540c\u7684\u7b56\u7565\u3002\u5982<strong>\u827e\u535a\u536b\u6cf0\u662f\u6211\u56fd\u81ea\u4e3b\u4ea7\u6743\u7684\u819c\u878d\u5408\u6291\u5236\u5242\u4e8e<\/strong><strong>2018<\/strong><strong>\u5e74\u4e0a\u5e02<\/strong>\u3002<\/p>\n<p><strong>CCR5\u62ee\u6297\u5242<\/strong><\/p>\n<p>\u7531\u4e8eCCR5\u5728HIV-1\u4f20\u64ad\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u5df2\u5c06\u5176\u4f5c\u4e3a\u6297\u75c5\u6bd2\u9776\u6807\u8fdb\u884c\u63a2\u7d22\u3002\u8868\u8fbeCCR5D32\u7a81\u53d8\u7684\u4e2a\u4f53\u5df2\u88ab\u8bc1\u660e\u662f\u5065\u5eb7\u7684\u5e76\u4e14\u51e0\u4e4e\u5b8c\u5168\u62b5\u6297HIV-1\u611f\u67d3<sup>[3]<\/sup>\u3002\u5df2\u5f00\u53d1\u591a\u79cdCCR5\u62ee\u6297\u5242\uff0c\u4f8b\u5982Maraviroc\u3001Aplaviroc\u3001TAK-779\u3001Vicriviroc\uff0c\u4ee5\u963b\u65adHIV-1\u8fdb\u5165\u3002<strong>Maraviroc<\/strong><strong>\u4e8e<\/strong><strong>2007<\/strong><strong>\u5e74<\/strong><strong>8<\/strong><strong>\u6708\u88ab<\/strong><strong>USFDA<\/strong><strong>\u6279\u51c6\u7684\u8fdb\u5165\u6291\u5236\u5242<\/strong><sup>[4]<\/sup>\u3002<\/p>\n<section>\n<section>\n<section><strong>\u9644\u7740\u6291\u5236\u5242<\/strong><\/p>\n<p>Rukobia\uff08fostemsavir\uff09\u4e0eHIV\u5916\u8868\u9762\u7684gp120\u86cb\u767d\u7ed3\u5408\uff0c\u5e72\u6270HIV\u5916\u8868\u9762\u4e0a\u7684gp120\u819c\u86cb\u767d\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u4e0a\u7684CD4\u53d7\u4f53\u4e4b\u95f4\u7684\u65e9\u671f\u76f8\u4e92\u4f5c\u7528\u3002\u4ece\u800c\u963b\u6b62HIV\u8fdb\u5165CD4\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section><strong>4<\/strong><\/p>\n<p><strong>\u9644\u7740\u540e\u6291\u5236\u5242<\/strong><\/p>\n<p>\u9644\u7740\u540e\u6291\u5236\u5242\u53ef\u963b\u65ad\u67d0\u4e9b\u514d\u75ab\u7ec6\u80de\u8868\u9762\u7684CD4\u53d7\u4f53\uff0c\u800cHIV\u9700\u8981\u8fd9\u4e9b\u53d7\u4f53\u624d\u80fd\u8fdb\u5165\u7ec6\u80de\u3002\u9644\u7740\u540e\u6291\u5236\u5242\u662f\u79f0\u4e3a\u8fdb\u5165\u6291\u5236\u5242\u7684\u4e00\u5927\u7c7bHIV\u836f\u7269\u7684\u4e00\u90e8\u5206\u3002<\/p>\n<p>Ibalizumab\u662f\u4e00\u7c7bCD4\u7279\u5f02\u6027\u6297\u4f53\uff0c\u4f5c\u7528\u90e8\u4f4d\u662fCD4\u4e0agp120\u7ed3\u5408\u4f4d\u70b9\u5bf9\u4fa7\u7684D1-D2\u8fde\u63a5\u70b9\u9644\u8fd1\u7684\u4e00\u4e2a\u8868\u4f4d\u3002\u5728\u4e00\u9879III\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u5bf9\u591a\u91cd\u8010\u836f\uff08Multi-drug Resistance, MDR\uff09\u60a3\u8005\u663e\u793a\u51fa\u660e\u663e\u7684\u6297\u75c5\u6bd2\u6548\u529b\u540e<strong>\uff0c<\/strong><strong>Ibalizumab<\/strong><strong>\u4e8e<\/strong><strong>2018<\/strong><strong>\u5e74<\/strong><strong>3<\/strong><strong>\u6708\u88ab\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08<\/strong><strong>USFDA<\/strong><strong>\uff09\u6279\u51c6<\/strong><sup>[5]<\/sup>\uff0c\u5bf9\u90a3\u4e9bMDR\u60a3\u8005\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n<p>\u8fdb\u5165\u6291\u5236\u5242\u5177\u6709\u9ad8\u7279\u5f02\u6027\u4f46\u526f\u4f5c\u7528\u6700\u5c0f\u7684\u7279\u6027\uff0c\u6709\u52a9\u4e8e\u5bf9\u827e\u6ecb\u75c5\u7684\u516c\u5171\u63aa\u65bd\u63a7\u5236\uff0c\u4f7f\u5f97\u516c\u5171\u5b89\u5168\u7684\u5371\u673a\u8d8a\u6765\u8d8a\u5c0f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54c1\u9500\u552e\u673a\u6784\uff1f","protected":false},"author":2,"featured_media":4081,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5,3,4],"tags":[55,135,200],"_links":{"self":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/4080"}],"collection":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4080"}],"version-history":[{"count":1,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/4080\/revisions"}],"predecessor-version":[{"id":4082,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/4080\/revisions\/4082"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/media\/4081"}],"wp:attachment":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4080"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4080"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}