{"id":3834,"date":"2024-04-26T05:15:48","date_gmt":"2024-04-25T21:15:48","guid":{"rendered":"http:\/\/baijianyy.cn\/?p=3834"},"modified":"2024-04-26T05:15:48","modified_gmt":"2024-04-25T21:15:48","slug":"%e7%9b%8a%e9%98%b3%e5%b8%82%e6%a1%83%e6%b1%9f%e5%8e%bfhiv%e4%ba%8b%e5%89%8d%e9%a2%84%e9%98%b2%e5%92%8c%e4%ba%8b%e5%90%8e%e9%98%bb%e6%96%ad%e7%9a%84%e5%8c%ba%e5%88%ab","status":"publish","type":"post","link":"http:\/\/baijianyy.cn\/?p=3834","title":{"rendered":"\u76ca\u9633\u5e02\u6843\u6c5f\u53bfHIV\u4e8b\u524d\u9884\u9632\u548c\u4e8b\u540e\u963b\u65ad\u7684\u533a\u522b"},"content":{"rendered":"<p>\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54c1\u9500\u552e\u673a\u6784\uff1f<br \/>\npep\u963b\u65ad\u836f\u3001prep\u963b\u65ad\u836f\u5168\u56fd\u4e24\u5c0f\u65f6\u6025\u9001\uff0c\u836f\u5e97\u76f4\u53d1\uff0c\u4e13\u4eba\u4e13\u9001<br \/>\n\u827e\u6ecb\u75c5HIV\u66b4\u9732\u524d\u540e\u963b\u65ad\u9884\u9632\u7528\u836f\uff0c\u8bf7\u626b\u7801\u6dfb\u52a0\u533b\u9662\u5ba2\u670d\uff0c\u5168\u56fd\u5404\u57ce\u5e02\u6700\u5feb2\u5c0f\u65f6\u5de6\u53f3\u9001\u8fbe\u3002<br \/>\n\u9ad8\u5371\u884c\u4e3a\u540e\u591a\u4e45\u68c0\u6d4b\uff1f\u9ad8\u5371\u6027\u884c\u4e3a\u4e00\u6b21\u8981\u5403\u963b\u65ad\u836f\u5417\uff1f\u53d1\u751f\u9ad8\u5371\u6027\u884c\u4e3a\u540e\u600e\u4e48\u529e\uff1f\u9ad8\u5371\u884c\u4e3a\u591a\u5c11\u5929\u540e\u53ef\u4ee5\u5f7b\u5e95\u6392\u9664\uff1f\u7b49\u7b49\u95ee\u9898\uff0c\u53ef\u4ee5\u5728\u4e92\u8054\u7f51\u533b\u9662\u514d\u8d39\u54a8\u8be2\u4e13\u4e1a\u611f\u67d3\u79d1\u533b\u5e08\u3002<img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-3682\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2024\/04\/mmexport1702183130138-1-1.gif\" alt=\"\" width=\"300\" height=\"300\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u76ca\u9633\u5e02\u6843\u6c5f\u53bf\u6b64\u95ee\u9898\u8bf7\u626b\u4e0a\u9762\u7684\u7801\u5173\u6ce8\u4e92\u8054\u7f51\u533b\u9662\uff0c\u4e3a\u60a8\u89e3\u7b54<\/p>\n<p>\u6843\u6c5f\u53bf\u81ea\u613f\u54a8\u8be2\u68c0\u6d4b\u673a\u6784\uff1a\u6843\u6c5f\u53bf\u4e2d\u533b\u533b\u9662 \u6e56\u5357\u7701\u76ca\u9633\u5e02\u6843\u6c5f\u53bf\u6843\u82b1\u6c5f\u9547\u5efa\u8bbe\u8def292\u53f7<\/p>\n<p><strong>1. \u4ec0\u4e48\u662fHIV\u66b4\u9732\u524d\u9884\u9632\uff1f<\/strong><\/p>\n<p>HIV\u66b4\u9732\u524d\u9884\u9632\uff08\u82f1\u6587Pre-exposure Prophylaxis\uff0c\u7b80\u79f0PrEP\uff09\u662f\u6307\u5f53\u4eba\u9762\u4e34HIV\u611f\u67d3\u9ad8\u98ce\u9669\u65f6\uff0c\u901a\u8fc7\u670d\u7528\u836f\u7269\u4ee5\u964d\u4f4e\u88ab\u611f\u67d3\u6982\u7387\u7684\u751f\u7269\u5b66\u9884\u9632\u65b9\u6cd5<sup>[1,2,3]<\/sup>\u3002\u6613\u611f\u67d3HIV\u7684\u884c\u4e3a\u4e3b\u8981\u5305\u62ec\u5171\u7528\u6ce8\u5c04\u5668\u5438\u6bd2\u3001\u591a\u6027\u4f34\u53ca\u65e0\u4fdd\u62a4\u6027\u884c\u4e3a\u7b49\u3002<\/p>\n<p><strong>2. \u66b4\u9732\u524d\u9884\u9632\u7528\u836f\u7684\u6548\u679c\u5982\u4f55\uff1f<\/strong><\/p>\n<p>PrEP\u7684\u6548\u679c\u5df2\u88ab\u5168\u7403\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u4e14\u56fd\u9645\u6d41\u884c\u75c5\u5b66\u6570\u636e\u663e\u793a\uff0c\u4f7f\u7528PrEP\u53ef\u5728\u516c\u5171\u536b\u751f\u5c42\u9762\u6709\u6548\u904f\u5236HIV\u4f20\u64ad<sup>[4,5]<\/sup>\u30022021\u7248\u7684\u300a\u4e2d\u56fd\u827e\u6ecb\u75c5\u8bca\u7597\u6307\u5357\u300b\u4e5f\u63a8\u8350\u5176\u4f5c\u4e3aHIV\u611f\u67d3\u9ad8\u5371\u4eba\u7fa4<a href=\"http:\/\/baijianyy.cn\/?tag=%e9%a2%84%e9%98%b2hiv%e6%84%9f%e6%9f%93\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u9884\u9632HIV\u611f\u67d3\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">\u9884\u9632HIV\u611f\u67d3<\/a>\u7684\u63aa\u65bd<sup>[1]<\/sup>\u3002\u670d\u836f\u4f9d\u4ece\u6027\u662f\u5f71\u54cdPrEP\u6709\u6548\u6027\u7684\u91cd\u8981\u56e0\u7d20\uff0c\u53d7\u8bd5\u4eba\u7fa4\u4e2d\u53e3\u670dPrEP\u836f\u7269\u7684\u4f9d\u4ece\u6027\u8d8a\u9ad8\uff0c\u9884\u9632HIV\u611f\u67d3\u7684\u6548\u679c\u8d8a\u597d\u3002\u53cd\u4e4b\uff0c\u670d\u836f\u4e0d\u89c4\u5f8b\uff0c\u7ecf\u5e38\u6f0f\u670d\uff0c\u9884\u9632\u6548\u679c\u5219\u4f1a\u8f83\u5dee\u3002\u7814\u7a76\u53d1\u73b0<sup>[6-9]<\/sup>\uff0c\u6709\u7684\u4eba\u670d\u7528\u4e86\u9884\u9632\u836f\u7269\u540e\u4ecd\u53d1\u751fHIV\u9633\u8f6c\uff0c\u672a\u80fd\u575a\u6301\u670d\u7528\u836f\u7269\u662f\u9884\u9632\u5931\u8d25\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/p>\n<p><strong>3.<\/strong><strong>\u54ea\u4e9b\u4eba\u7fa4\u9002\u5408\u4f7f\u7528PrEP\u9884\u9632HIV\u611f\u67d3\uff1f<\/strong><\/p>\n<p>\u9700\u8981\u5f3a\u8c03\u7684\u662f\uff0c\u5e76\u975e\u6240\u6709HIV\u9634\u6027\u8005\u90fd\u9002\u5408\u4f7f\u7528PrEP\uff0c\u53ea\u6709\u90a3\u4e9b\u5904\u4e8eHIV\u9ad8\u66b4\u9732\u98ce\u9669\u7684\u4eba\u5458\u624d\u9002\u5408\u3002\u7531\u4e8e\u66b4\u9732\u524d\u9884\u9632\u7528\u836f\u4e3a\u5904\u65b9\u836f\u7269\uff0c\u4e3a\u786e\u4fddPrEP\u7528\u836f\u89c4\u8303\u548c\u76f8\u5173\u5b89\u5168\u6027\uff0c\u542f\u52a8PrEP\u4e4b\u524d\u533b\u52a1\u4eba\u5458\u9700\u8981\u5bf9\u6c42\u8bca\u8005\u8fdb\u884cHIV\u66b4\u9732\u98ce\u9669\u8bc4\u4f30\u548c\u533b\u5b66\u9002\u7528\u6027\u8bc4\u4f30\uff0c\u4e14\u5728\u8bc4\u4f30\u7b26\u5408\u8981\u6c42\u540e\u624d\u80fd\u542f\u52a8PrEP\u3002\u603b\u4e4b\uff0cPrEP\u5e94\u5728\u4e13\u4e1a\u4eba\u5458\u6307\u5bfc\u4e0b\u4f7f\u7528<sup>[2]<\/sup>\u3002<\/p>\n<p><strong>4. \u66b4\u9732\u524d\u9884\u9632\u836f\u7269\u6709\u54ea\u4e9b\uff1f<\/strong><\/p>\n<p>\u76ee\u524d\u6b27\u6d32\u548c\u7f8e\u56fd\u6307\u5357\u63a8\u8350\u4f7f\u7528\u7684PrEP\u836f\u7269\u65b9\u6848\u4e3a\u66ff\u8bfa\u798f\u97e6\u916f\uff08tenofovir disoproxil fumarate,TDF\uff09\u4e0e\u6069\u66f2\u4ed6\u6ee8\uff08emtricitabine,FTC\uff09\uff08TDF\/FTC\uff09\u3002\u800cWHO\u6307\u5357\u9664\u4e86\u63a8\u8350TDF\/FTC\u4f5c\u4e3a\u66b4\u9732\u524d\u9884\u9632\u7528\u836f\u5916\uff0c\u540c\u65f6\u5efa\u8bae\u4f7f\u7528TDF\u548c\u62c9\u7c73\u592b\u5b9a\uff083TC\uff09\uff08\u5373TDF\/3TC\uff09\u4f5c\u4e3aPrEP\u7684\u670d\u836f\u65b9\u6848\u3002WHO\u8ba4\u4e3aFTC\u548c3TC\u65e0\u8bba\u5728HIV\u611f\u67d3\u6cbb\u7597\u8fd8\u662f\u9884\u9632\u65b9\u9762\u90fd\u662f\u5f7c\u6b64\u53ef\u4ee5\u66ff\u4ee3\u7684\u836f\u7269\u3002\u4e0d\u8fc7\uff0c\u76ee\u524d\u5c1a\u7f3a\u4e4f\u57fa\u4e8e3TC\u836f\u7269\u65b9\u6848\u7684PrEP\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u3002\u5f53\u524d\u4e2d\u56fd\u3001\u7f8e\u56fd\u548c\u6b27\u76df\u5747\u672a\u6279\u51c63TC\u7684PrEP\u836f\u7269\u9002\u5e94\u8bc1<sup>[2]<\/sup>\u3002\u56e0\u6b64\uff0c\u6211\u56fd\u91c7\u7528\u7684\u662f\u5df2\u88ab\u6279\u51c6\u836f\u7269\u9002\u5e94\u8bc1\u7684TDF\/FTC\u4f5c\u4e3aPrEP\u7684\u670d\u836f\u65b9\u6848\u3002<\/p>\n<p><strong>5. \u66b4\u9732\u524d\u9884\u9632\u7528\u836f\u600e\u4e48\u7528\uff1f<\/strong><\/p>\n<p>\u56fd\u9645\u4e0a\u53e3\u670dTDF\/FTC\uff08300mg \/200 mg\uff09\u7528\u4e8ePrEP\u7684\u670d\u836f\u65b9\u5f0f\u4e3b\u8981\u6709\u4e24\u79cd<sup>[2]<\/sup>\uff0c\u5206\u522b\u4e3a\u6bcf\u65e5\u670d\u836f\u65b9\u6848\u548c\u4e8b\u4ef6\u9a71\u52a8\u670d\u836f\u65b9\u6848\uff08event-driven, ED-PrEP\uff09\u53c8\u79f0\u6309\u9700\uff08on-demand\uff09\u670d\u836f\u65b9\u6848\u3002\uff081\uff09\u6bcf\u65e5\u670d\u836f\u65b9\u6848\uff1a\u6bcf24\u5c0f\u65f6\u53e3\u670d1\u7247TDF\/FTC\u3002\uff082\uff09\u6309\u9700\u670d\u836f\u65b9\u6848\uff1a\u6307\u5728\u9884\u671f\u6027\u884c\u4e3a\u53d1\u751f\u524d2~24\u5c0f\u65f6\u53e3\u670d2\u7247TDF\/FTC\uff0c\u5728\u6027\u884c\u4e3a\u540e\uff0c\u8ddd\u4e0a\u6b21\u670d\u836f24\u5c0f\u65f6\u670d\u836f1\u7247\uff0c48\u5c0f\u65f6\u518d\u670d\u75281\u7247TDF\/FTC\uff0c\u5373\u6240\u8c13\u201c2+1+1\u201dPrEP\u6309\u9700\u670d\u836f\u65b9\u5f0f\uff0c\u89c1\u56fe1<sup>[2]<\/sup>\u3002<img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-3845\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2024\/04\/640-14-1.png\" alt=\"\" width=\"554\" height=\"158\" \/><\/p>\n<section>\n<section>\n<section>\u56fe1 PrEP \u6309\u9700\u670d\u836f\u793a\u610f\u56fe<\/p>\n<\/section>\n<section>\u73b0\u6709\u7814\u7a76\u663e\u793a\uff0c\u6bcf\u65e5\u670d\u836f\u65b9\u6848\u5728\u5404\u7c7b\u9ad8\u5371\u4eba\u7fa4\u5747\u8bc1\u5b9e\u5177\u6709\u826f\u597d\u9884\u9632HIV\u6548\u679c\u3002\u800c\u6309\u9700\u670d\u836f\u65b9\u6848\u4ec5\u9002\u7528\u4e8e\u751f\u7406\u6027\u522b\u4e3a\u7537\u6027\u8005\u9884\u9632\u6027\u9014\u5f84\u4f20\u64ad<sup>[10]<\/sup>\u3002<\/p>\n<p><strong>6. \u670d\u7528\u4e86\u66b4\u9732\u524d\u9884\u9632\u7528\u836f\u662f\u5426\u4ecd\u8981\u4f7f\u7528\u5b89\u5168\u5957\uff1f<\/strong><\/p>\n<p>\u9700\u8981\u3002\u66b4\u9732\u524d\u9884\u9632\u7528\u836f\u4e0d\u80fd\u53d6\u4ee3\u73b0\u6709\u7684HIV\u9884\u9632\u63aa\u65bd\uff0c\u6bd4\u5982\u6b63\u786e\u4f7f\u7528\u5b89\u5168\u5957<sup>[3,11]<\/sup>\u3002PrEP\u670d\u836f\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u4f9d\u4ece\u6027\u4e0d\u597d\u3001\u51fa\u73b0\u6f0f\u670d\u7b49\uff0c\u4f1a\u5f71\u54cd\u836f\u7269\u9884\u9632\u7684\u6548\u679c\uff0c\u52a0\u4e4b\u66b4\u9732\u524d\u9884\u9632\u7528\u836f\u4e0d\u80fd\u9884\u9632\u5176\u4ed6\u6027\u75c5\u611f\u67d3\uff0c\u56e0\u6b64\u4f9d\u7136\u6709\u5fc5\u8981\u4f7f\u7528\u5b89\u5168\u5957\uff0c\u4ee5\u9884\u9632\u6dcb\u75c5\u3001\u8863\u539f\u4f53\u611f\u67d3\u7b49\u5176\u4ed6\u7ecf\u7cbe\u6db2\u6216\u9634\u9053\u5206\u6ccc\u7269\u4f20\u64ad\u7684\u6027\u75c5<sup>[11]<\/sup>\u3002\u5f53\u7136\uff0c\u4f7f\u7528\u5b89\u5168\u5957\u4e5f\u4e0d\u80fd\u5b8c\u5168\u9884\u9632HPV\uff08\u5982\u5c16\u9510\u6e7f\u75a3\uff09\u3001\u751f\u6b96\u5668\u75b1\u75b9\u548c\u6885\u6bd2\u7b49\u53ef\u80fd\u7ecf\u75ae\u6216\u76ae\u80a4\u7834\u635f\u4f20\u64ad\u7684\u6027\u75c5<sup>[12]<\/sup>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><strong>\u827e\u6ecb\u75c5\u75c5\u6bd2\uff08HIV\uff09\u66b4\u9732\u540e\u9884\u9632<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section><\/section>\n<section><strong>1. \u4ec0\u4e48\u662fHIV\u66b4\u9732\u540e\u9884\u9632\uff1f<\/strong><\/p>\n<p>HIV\u66b4\u9732\u540e\u9884\u9632\uff08Post-exposure Prophylaxis\uff0cPEP\uff09\u662f\u6307\uff1a\u5c1a\u672a\u611f\u67d3HIV\u7684\u4eba\u5458\uff0c\u5728\u66b4\u9732\u4e8e\u9ad8\u611f\u67d3\u98ce\u9669\u540e\uff0c\u5982\u4e0eHIV\u611f\u67d3\u8005\u6216\u611f\u67d3\u72b6\u6001\u4e0d\u660e\u8005\u53d1\u751f\u4f53\u6db2\u4ea4\u6362\u884c\u4e3a\uff0c\u53ca\u65e9\uff08\u4e0d\u8d85\u8fc772\u5c0f\u65f6\uff09\u670d\u7528\u7279\u5b9a\u7684\u6297\u75c5\u6bd2\u836f\u7269\uff0c\u964d\u4f4eHIV\u611f\u67d3\u98ce\u9669\u7684\u65b9\u6cd5<sup>[13]<\/sup>\u3002<\/p>\n<p><strong>2. \u66b4\u9732\u540e\u9884\u9632\u7684\u6548\u679c\u5982\u4f55\uff1f<\/strong><\/p>\n<p>\u4f5c\u4e3a\u4e00\u79cd\u9884\u9632HIV\u611f\u67d3\u7684\u91cd\u8981\u63aa\u65bd\uff0c\u8bb8\u591a\u56fd\u5bb6\u5bf9PEP\u8fdb\u884c\u4e86\u5927\u91cf\u79d1\u5b66\u7814\u7a76\u548c\u5e94\u7528\u3002\u5c3d\u7ba1\u7531\u4e8e\u4f26\u7406\u5b66\u7b49\u539f\u56e0\uff0c\u56fd\u9645\u4e0a\u5c1a\u7f3a\u4e4f\u6709\u5173PEP\u6548\u679c\u7684\u968f\u673a\u5bf9\u7167\u7814\u7a76\uff0c\u4f46\u6fb3\u5927\u5229\u4e9a\u3001\u82f1\u56fd\u3001\u7f8e\u56fd\u7b49\u56fd\u5df2\u5f00\u5c55\u591a\u9879\u89c2\u5bdf\u6027\u7814\u7a76\uff0c\u8bc1\u5b9e\u5176\u5177\u6709\u826f\u597d\u7684\u9884\u9632\u6548\u679c\u3002PEP\u5df2\u7ecf\u5728\u5f88\u591a\u56fd\u5bb6\u5e94\u7528\uff0c\u6709\u6548\u51cf\u5c11\u4e86\u66b4\u9732\u540e\u4f20\u64ad\u3002\u6211\u56fd\u804c\u4e1a\u66b4\u9732\u540e\u9884\u9632\u5de5\u4f5c\u5df2\u7ecf\u5f00\u5c55\u4e86\u4e8c\u5341\u591a\u5e74\uff0c\u5b9e\u65bd\u66b4\u9732\u540e\u9884\u9632\u4e0a\u5343\u4f8b\uff0c\u5c1a\u65e0\u963b\u65ad\u5931\u8d25\u7684\u6848\u4f8b\uff0c\u53ef\u89c1PEP\u9884\u9632\u6548\u679c\u826f\u597d<sup>[13]<\/sup>\u3002<\/p>\n<p>\u6210\u529f\u7387\u4e0e\u9996\u6b21\u670d\u836f\u53ca\u65f6\u6027\u53ca\u670d\u836f\u4f9d\u4ece\u6027\u6709\u5173\uff0c\u66b4\u9732\u540e\u8d8a\u65e9\u670d\u836f\uff0c\u963b\u65ad\u6210\u529f\u7387\u8d8a\u9ad8\u3002\u53d1\u751fHIV\u66b4\u9732\u540e\uff0c\u5e94\u5c3d\u53ef\u80fd\u5728\u6700\u77ed\u7684\u65f6\u95f4\u5185\uff08\u5c3d\u53ef\u80fd\u57282\u5c0f\u65f6\u5185\uff09\u8fdb\u884c\u9884\u9632\u6027\u7528\u836f\uff0c\u6700\u597d\u572824\u5c0f\u65f6\u5185\u3001\u4e0d\u8d85\u8fc772\u5c0f\u65f6\uff0c\u8fde\u7eed\u670d\u752828\u5929<sup>[1]<\/sup>\u3002\u670d\u836f\u5f00\u59cb\u540e\uff0c\u6bcf\u5929\u89c4\u5f8b\u670d\u836f\u6bd4\u7ecf\u5e38\u6f0f\u670d\u963b\u65ad\u6548\u679c\u597d\u3002<\/p>\n<p><strong>3. \u54ea\u7c7b\u4eba\u7fa4\u9002\u7528\u4f7f\u7528PEP\u9884\u9632HIV\u611f\u67d3?<\/strong><\/p>\n<p>\u6240\u6709\u4e0e\u66b4\u9732\u6e90\u53d1\u751f\u4e86\u53ef\u80fd\u5bfc\u81f4HIV\u611f\u67d3\u884c\u4e3a\u7684\u4eba\uff0c\u5747\u63a8\u8350\u5c3d\u65e9\u4f7f\u7528PEP\u3002\u66b4\u9732\u6e90\u5305\u62ec\u660e\u786e\u7684\u6216\u6f5c\u5728\u7684HIV\u611f\u67d3\u8005\u3002PEP\u9002\u7528\u4eba\u7fa4\u5305\u62ec\u7537\u7537\u6027\u884c\u4e3a\u8005\u53ca\u8de8\u6027\u522b\u5973\u6027\u3001HIV\u611f\u67d3\u8005\u7684\u6027\u4f34\u3001\u9759\u8109\u6ce8\u5c04\u5438\u6bd2\u8005\u3001\u5176\u4ed6\u6709\u9ad8\u98ce\u9669\u884c\u4e3a\u7684\u5f02\u6027\u6027\u884c\u4e3a\u8005\u3001\u6027\u4fb5\u53d7\u5bb3\u8005\u7b49<sup>[13]<\/sup>\u3002<\/p>\n<p>PEP\u4f7f\u7528\u7684\u7eb3\u5165\u6807\u51c6<sup>[13]<\/sup>\uff08\u5168\u90e8\u7b26\u5408\u4ee5\u4e0b5\u6761\u8005\u65b9\u53ef\u7eb3\u5165\uff09\uff1a\uff081\uff09\u5e74\u9f84 18 \u5468\u5c81\u53ca\u4ee5\u4e0a\uff0c\u4e0d\u8db318\u5c81\u9700\u76d1\u62a4\u4eba\u540c\u610f\uff1b\uff082\uff09HIV\u6297\u4f53\u68c0\u6d4b\u9634\u6027\uff1b\uff083\uff09\u66b4\u9732\u65f6\u95f4\u4e0d\u8d85\u8fc772\u5c0f\u65f6\uff1b\uff084\uff09\u66b4\u9732\u6e90\u53ca\u884c\u4e3a\u8bc4\u4f30\u5206\u6790\u63d0\u793a\u6c42\u8be2\u8005HIV\u611f\u67d3\u98ce\u9669\u8f83\u9ad8\uff1b\uff085\uff09\u540c\u610f\u6309\u65f6\u670d\u836f\u3001\u4fdd\u8bc1\u4f9d\u4ece\u6027\u3001\u6309\u65f6\u53c2\u52a0\u968f\u8bbf\u68c0\u6d4b\u3002<\/p>\n<p>\u7531\u4e8e\u66b4\u9732\u540e\u9884\u9632\u7528\u836f\u4e3a\u5904\u65b9\u836f\u7269\uff0c\u4e3a\u786e\u4fddPEP\u7528\u836f\u89c4\u8303\u548c\u76f8\u5173\u5b89\u5168\u6027\uff0c\u5728\u5f00\u59cbPEP\u4e4b\u524d\u533b\u52a1\u4eba\u5458\u9700\u8981\u5bf9\u5373\u5c06\u670d\u836f\u8005\u8fdb\u884c\u9002\u7528\u6027\u8bc4\u4f30\uff0c\u4e14\u5728\u8bc4\u4f30\u7b26\u5408\u8981\u6c42\u540e\u624d\u80fd\u4f7f\u7528PEP\uff0c\u5e76\u5728\u542f\u52a8\u670d\u836f\u540e\u8fdb\u884c\u968f\u8bbf\u3002\u603b\u4e4b\uff0cPEP\u5e94\u5728\u4e13\u4e1a\u4eba\u5458\u6307\u5bfc\u4e0b\u4f7f\u7528\u3002<\/p>\n<p><strong>4. \u66b4\u9732\u540e\u9884\u9632\u836f\u7269\u6709\u54ea\u4e9b\uff1f<\/strong><\/p>\n<p>PEP\u7528\u836f\u91c7\u7528\u4e09\u79cd\u6297\u75c5\u6bd2\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u539f\u5219\u4e0a\uff0c\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u7b49\u56fd\u9645\u76f8\u5173\u673a\u6784\u53d1\u5e03\u7684\u6307\u5357\u4e2d\u63a8\u8350\u7684\u53ef\u7528\u4e8ePEP\u7684\u836f\u7269\u5747\u53ef\u4f7f\u7528\u3002\u76ee\u524d\u5e38\u7528\u7684PEP\u65b9\u6848\u5305\u62ec\uff1a\uff08TDF\u6216TAF\uff0c Tenofovir Alafenamide \u66ff\u8bfa\u798f\u97e6\u827e\u62c9\u915a\u80fa\uff0c\u4e8c\u9009\u4e00\uff09+\uff08FTC\u62163TC\uff0c\u4e8c\u9009\u4e00\uff09+\uff08DTG Dolutegravir \u591a\u66ff\u62c9\u97e6\u94a0 \u6216 RAL Raltegravir \u62c9\u66ff\u62c9\u97e6\u94be\uff0c\u4e8c\u9009\u4e00\uff09\uff0c\u66ff\u8bfa\u798f\u97e6\u548cFTC\uff08\u6216\u80053TC\uff09\u4e5f\u53ef\u4ee5\u7528\u6069\u66f2\u4ed6\u6ee8\u66ff\u8bfa\u798f\u97e6\u7247\u6216\u62c9\u7c73\u592b\u5b9a\u66ff\u8bfa\u798f\u97e6\u7247\u4e8c\u5408\u4e00\u7247\u5242\u4ee3\u66ff,\u8fde\u7eed\u670d\u836f28\u5929\u3002\u533b\u52a1\u4eba\u5458\u5e94\u6839\u636e\u6c42\u8be2\u8005\u5177\u4f53\u60c5\u51b5\uff08\u5982\uff1a\u63a5\u53d7\u7f8e\u6c99\u916e\u6cbb\u7597\u3001\u6297\u7ed3\u6838\u6cbb\u7597\u3001\u598a\u5a20\u7b49\uff09\u53ca\u5f53\u5730\u836f\u7269\u53ef\u53ca\u6027\uff0c\u4e3a\u6c42\u8be2\u8005\u5c3d\u91cf\u9009\u62e9\u526f\u4f5c\u7528\u8f83\u5c0f\u3001\u9002\u5b9c\u7684\u7528\u836f\u65b9\u6848<sup>[13]<\/sup>\u3002<\/p>\n<p><strong>5. \u66b4\u9732\u540e\u9884\u9632\u7528\u836f\u600e\u4e48\u7528\uff1f<\/strong><\/p>\n<p>\u4e0eHIV\u611f\u67d3\u8005\u6216\u611f\u67d3\u72b6\u51b5\u4e0d\u660e\u8005\u53d1\u751f\u6613\u611f\u67d3HIV\u7684\u884c\u4e3a\u540e\uff0c\u572872\u5c0f\u65f6\u4e4b\u5185\u670d\u7528\u963b\u65ad\u836f\uff0c\u670d\u836f\u8d8a\u65e9\uff0c\u963b\u65ad\u6548\u679c\u8d8a\u597d\uff0c\u8fde\u7eed\u670d\u752828\u5929\u3002\u90e8\u5206\u670d\u836f\u8005\u53ef\u80fd\u51fa\u73b0\u836f\u7269\u526f\u4f5c\u7528\uff0c\u5e38\u89c1\u7684\u5982\u5934\u75db\u3001\u5931\u7720\u3001\u7729\u6655\u3001\u75b2\u52b3\u4ee5\u53ca\u6076\u5fc3\u3001\u5455\u5410\u6216\u8005\u80c3\u80a0\u80c0\u6c14\u7b49\uff0c\u4e0a\u8ff0\u75c7\u72b6\u901a\u5e38\u4e3a\u4e00\u8fc7\u6027\u3002\u5982\u679c\u836f\u7269\u526f\u4f5c\u7528\u6301\u7eed\u65f6\u95f4\u957f\u6216\u52a0\u91cd\uff0c\u8981\u53ca\u65f6\u5c31\u533b\u8fdb\u884c\u5bf9\u75c7\u5904\u7406<sup>[13]<\/sup>\u3002<\/p>\n<p><strong>6. \u670d\u7528\u4e86\u66b4\u9732\u540e\u9884\u9632\u836f\u662f\u5426\u4ecd\u8981\u4f7f\u7528\u5b89\u5168\u5957\uff1f<\/strong><\/p>\n<p>PEP\u4e0d\u80fd\u9884\u9632\u5176\u4ed6\u6027\u75c5\u611f\u67d3\u3002\u56e0\u6b64\uff0c\u4f7f\u7528PEP\u671f\u95f4\u4ecd\u5e94\u575a\u6301\u4f7f\u7528\u5b89\u5168\u5957\uff0c\u907f\u514d\u611f\u67d3\u5176\u4ed6\u6027\u75c5<sup>[13]<\/sup>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54c1\u9500\u552e\u673a\u6784\uff1f","protected":false},"author":4,"featured_media":3845,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5,3,4,57],"tags":[266,48,352,135],"_links":{"self":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/3834"}],"collection":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3834"}],"version-history":[{"count":1,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/3834\/revisions"}],"predecessor-version":[{"id":3846,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/3834\/revisions\/3846"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/media\/3845"}],"wp:attachment":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3834"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}