{"id":2510,"date":"2024-03-02T16:41:26","date_gmt":"2024-03-02T08:41:26","guid":{"rendered":"http:\/\/baijianyy.cn\/?p=2510"},"modified":"2024-03-02T16:41:26","modified_gmt":"2024-03-02T08:41:26","slug":"%e6%ad%a6%e6%b1%89%e5%b8%82%e6%b1%9f%e5%a4%8f%e5%8c%ba%e9%98%bb%e6%96%ad%e8%8d%af%e5%af%b9%e8%82%9d%e8%84%8f%e6%8d%9f%e4%bc%a4%e5%a4%a7%e5%90%97%e6%9b%b4%e6%8c%81%e4%b9%85%e7%9a%84%e6%8a%97%e8%89%be","status":"publish","type":"post","link":"http:\/\/baijianyy.cn\/?p=2510","title":{"rendered":"\u6b66\u6c49\u5e02\u6c5f\u590f\u533a\u963b\u65ad\u836f\u5bf9\u809d\u810f\u635f\u4f24\u5927\u5417?\u66f4\u6301\u4e45\u7684\u6297\u827e\u6ecb\u75c5\u836f\u7269\u5373\u5c06\u95ee\u4e16\uff0c\u672a\u6765\u611f\u67d3\u8005\u4e0d\u9700\u8981\u6bcf\u5929\u670d\u836f\u4e86"},"content":{"rendered":"<p>\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54c1\u9500\u552e\u673a\u6784\uff1f<br \/>\npep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u3001prep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u5168\u56fd\u4e24\u5c0f\u65f6\u6025\u9001\uff0c\u836f\u5e97\u76f4\u53d1\uff0c\u4e13\u4eba\u4e13\u9001<\/p>\n<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85\" target=\"_blank\" rel=\"noopener\">\u827e\u6ecb\u75c5<\/a>HIV\u66b4\u9732\u524d\u540e\u963b\u65ad\u9884\u9632\u7528\u836f\uff0c\u8bf7\u626b\u7801\u6dfb\u52a0\u533b\u9662\u5ba2\u670d\uff0c<strong>\u5168\u56fd\u5404\u57ce\u5e02<\/strong>\u6700\u5feb2\u5c0f\u65f6\u5de6\u53f3\u9001\u8fbe\u3002<\/p>\n<p>\u9ad8\u5371\u884c\u4e3a\u540e\u591a\u4e45\u68c0\u6d4b\uff1f\u9ad8\u5371\u6027\u884c\u4e3a\u4e00\u6b21\u8981\u5403\u963b\u65ad\u836f\u5417\uff1f\u53d1\u751f\u9ad8\u5371\u6027\u884c\u4e3a\u540e\u600e\u4e48\u529e\uff1f\u9ad8\u5371\u884c\u4e3a\u591a\u5c11\u5929\u540e\u53ef\u4ee5\u5f7b\u5e95\u6392\u9664\uff1f\u7b49\u7b49\u95ee\u9898\uff0c\u53ef\u4ee5\u5728\u4e92\u8054\u7f51\u533b\u9662\u514d\u8d39\u54a8\u8be2\u4e13\u4e1a\u611f\u67d3\u79d1\u533b\u5e08\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-127 aligncenter\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/mmexport1702183130138.gif\" alt=\"\" width=\"300\" height=\"300\" 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title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u6bd2\u6cbb\u7597\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">\u827e\u6ecb\u75c5\u6bd2\u6cbb\u7597<\/a>\u53d6\u5f97\u4e86\u957f\u8db3\u7684\u8fdb\u6b65\u2014\u2014\u4ece\u6bcf\u5929\u591a\u6b21\u670d\u7528\u5c11\u91cf\u836f\u7247\u5230\u6bcf\u5929\u4e00\u6b21\u7684\u5355\u7247\u6cbb\u7597\u65b9\u6848\u548c\u6bcf\u4e24\u4e2a\u6708\u6ce8\u5c04\u4e00\u6b21\u3002\u6bcf\u65e5\u670d\u836f\u548c\u6bcf\u9694\u4e00\u4e2a\u6708\u6ce8\u5c04\u4e00\u6b21\u4e5f\u53ef\u4ee5\u9884\u9632<a href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u6bd2\u611f\u67d3\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">\u827e\u6ecb\u75c5\u6bd2\u611f\u67d3<\/a>\u3002\u4f46\u4ecd\u7136\u9700\u8981\u66f4\u6301\u4e45\u7684\u9009\u62e9\uff0c\u56e0\u4e3a \u5728\u7f8e\u56fd\uff0c\u53ea\u6709\u7ea6\u4e09\u5206\u4e4b\u4e8c\u7684<a href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85%e6%af%92\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u6bd2\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">\u827e\u6ecb\u75c5\u6bd2<\/a>\u611f\u67d3\u8005\u5b9e\u73b0\u4e86\u75c5\u6bd2\u6291\u5236\uff0c\u5e76\u4e14\u53ea\u6709\u4e09\u5206\u4e4b\u4e00\u7684\u7b26\u5408\u6761\u4ef6\u7684\u4eba\u63a5\u53d7\u4e86\u66b4\u9732\u524d\u9884\u9632\uff08PrEP\uff09\u3002<\/p>\n<p>\u957f\u6548\u6cbb\u7597\u548c\u9884\u9632\u66f4\u65b9\u4fbf\u3001\u66f4\u8c28\u614e\uff0c\u5e76\u9f13\u52b1\u826f\u597d\u7684\u4f9d\u4ece\u6027\u3002\u7814\u7a76\u4e3a\u51cf\u5c11\u670d\u7528\u9891\u7387\u7684\u6cbb\u7597\u65b9\u6cd5\u5e26\u6765\u4e86\u5e0c\u671b\uff0c\u5e76\u4e14\u957f\u671f\u7f13\u89e3\u662f\u4e00\u4e2a\u5373\u5c06\u5230\u6765\u7684\u76ee\u6807\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u6548\u679c\u6700\u957f\u7684\u5b8c\u6574\u827e\u6ecb\u75c5\u6bd2\u6cbb\u7597\u65b9\u6848\u662f Cabenuva\uff08\u6ce8\u5c04\u7528\u5361\u535a\u7279\u97e6\u548c\u5229\u5339\u97e6\u6797\uff09\uff0c\u7531\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u6bcf\u4e00\u4e24\u4e2a\u6708\u6ce8\u5c04\u4e00\u6b21\u3002\u76ee\u524d\uff0c\u5b83\u4ec5\u88ab\u6279\u51c6\u7528\u4e8e\u75c5\u6bd2\u8f7d\u91cf\u65e0\u6cd5\u68c0\u6d4b\u5230\u3001\u5e0c\u671b\u6539\u7528\u65b0\u7597\u6cd5\u7684\u4eba\uff0c\u4f46\u6700\u8fd1\u7684\u8bd5\u70b9\u7814\u7a76\u8868\u660e\uff0c\u5b83\u4e5f\u9002\u7528\u4e8e\u6ca1\u6709\u75c5\u6bd2\u6291\u5236\u7684\u4eba\u3002\u5bf9\u4e8e HIV \u9884\u9632\uff0cApretude\uff08\u5355\u72ec\u6ce8\u5c04\u5361\u535a\u7279\u97e6\uff09\u7684\u6548\u679c\u751a\u81f3\u6bd4 PrEP \u836f\u4e38\u66f4\u597d\u3002<\/p>\n<p>\u53bb\u5e74 12 \u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6\u4e86 Sunlenca\uff08lenacapavir\uff09\uff0c\u8fd9\u662f\u7b2c\u4e00\u79cd HIV \u8863\u58f3\u6291\u5236\u5242\uff0c\u6bcf\u516d\u4e2a\u6708\u7ed9\u836f\u4e00\u6b21\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5b83\u4ec5\u9002\u7528\u4e8e\u6709\u6cbb\u7597\u7ecf\u9a8c\u7684\u591a\u91cd\u8010\u836f\u827e\u6ecb\u75c5\u6bd2\u60a3\u8005\uff0c\u4f46\u5b83\u5bf9\u4e8e\u521d\u59cb\u6cbb\u7597\u4e5f\u5f88\u6709\u6548\uff0c\u5e76\u4e14\u6b63\u5728\u9488\u5bf9 PrEP \u8fdb\u884c\u7814\u7a76\u3002Sunlenca \u662f\u7ecf\u6279\u51c6\u7684\u4f5c\u7528\u65f6\u95f4\u6700\u957f\u7684\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\uff0c\u4f46\u5b83\u4e0d\u80fd\u5355\u72ec\u4f7f\u7528\uff0c\u800c\u4e14\u7f3a\u4e4f\u540c\u6837\u6301\u4e45\u7684\u4f19\u4f34\u3002\u4e3a\u4e86\u586b\u8865\u8fd9\u4e00\u7a7a\u767d\uff0c\u5409\u5229\u5fb7\u79d1\u5b66\u516c\u53f8\u76ee\u524d\u6b63\u5728\u6d4b\u8bd5 Sunlenca \u4e0e\u4e24\u79cd\u5e7f\u6cdb\u4e2d\u548c\u6297\u4f53\u7684\u7ec4\u5408\uff0c\u4f5c\u4e3a\u4e00\u4e2a\u5b8c\u6574\u7684\u6bcf\u5e74\u4e24\u6b21\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<p>\u5728\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u8fc7\u7a0b\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u6b63\u5728\u63a2\u7d22\u5176\u4ed6\u957f\u6548\u7597\u6cd5\u3002\u897f\u96c5\u56fe\u534e\u76db\u987f\u5927\u5b66\u7684\u4e00\u4e2a\u56e2\u961f\u6b63\u5728\u6d4b\u8bd5\u4e00\u79cd\u7531\u5bcc\u9a6c\u9178\u66ff\u8bfa\u798f\u97e6\u4e8c\u5421\u544b\u916f\u3001\u62c9\u7c73\u592b\u5b9a\u548c\u6574\u5408\u9176\u6291\u5236\u5242\u591a\u66ff\u62c9\u97e6\uff08\u5355\u72ec\u4f5c\u4e3a\u7279\u5a01\u51ef\u5355\u72ec\u51fa\u552e\uff09\u7ec4\u6210\u7684\u7f13\u91ca\u6ce8\u5c04\u5236\u5242\u3002\u8fd9\u4e09\u79cd\u836f\u7269\u7684\u6bcf\u65e5\u53e3\u670d\u7ec4\u5408\uff08\u6709\u65f6\u79f0\u4e3a TLD\uff09\u662f\u5168\u4e16\u754c\u6700\u5e7f\u6cdb\u4f7f\u7528\u7684\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<p>\u6b63\u5982\u300a\u827e\u6ecb\u75c5\u300b\u6742\u5fd7\u4e2d\u6240\u63cf\u8ff0\u7684\u90a3\u6837\uff0c Simone Perazzolo \u535a\u58eb\u53ca\u5176\u540c\u4e8b\u4f7f\u7528\u4e86\u65b0\u578b\u836f\u7269\u7ec4\u5408\u7eb3\u7c73\u9897\u7c92\u6280\u672f\uff0c\u8be5\u6280\u672f\u53ef\u4ee5\u5c06\u6c34\u6eb6\u6027\u548c\u4e0d\u6eb6\u6027\u836f\u7269\u7ec4\u5408\u8d77\u6765\uff0c\u4ee5\u751f\u4ea7\u9700\u8981\u8f83\u5c11\u7ed9\u836f\u9891\u7387\u7684\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u836f\u7269\u7684\u7269\u7406\u548c\u5316\u5b66\u6027\u8d28\u4e0d\u540c\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u80fd\u591f\u7a33\u5b9a\u66ff\u8bfa\u798f\u97e6\u3001\u62c9\u7c73\u592b\u5b9a\u548c\u591a\u66ff\u62c9\u97e6\u5e76\u5c06\u5176\u7ec4\u88c5\u6210\u9002\u5408\u76ae\u4e0b\u6ce8\u5c04\u7684\u5236\u5242\uff0c\u4ed6\u4eec\u5c06\u5176\u79f0\u4e3a TLD-in-DcNP\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u4e0e\u5176\u4ed6\u4e00\u4e9b\u5f62\u6210\u201c\u50a8\u5b58\u5e93\u201d\u5e76\u968f\u7740\u65f6\u95f4\u7f13\u6162\u91ca\u653e\u836f\u7269\u7684\u957f\u6548\u836f\u7269\u4e0d\u540c\uff0cTLD-in-DcNP \u836f\u7269\u53ef\u4ee5\u88ab\u6dcb\u5df4\u7cfb\u7edf\u5feb\u901f\u3001\u5b8c\u5168\u5438\u6536\uff0c\u5728\u6ce8\u5c04\u90e8\u4f4d\u6ca1\u6709\u660e\u663e\u6ede\u7559\u3002<\/p>\n<p>\u5728\u4e00\u9879\u65e9\u671f\u7814\u7a76\u4e2d\uff0c\u5f53\u5c06 TLD-in-DcNP \u7ed9\u4e88\u7334\u5b50\u65f6\uff0c\u4e0e\u6eb6\u89e3\u5728\u6db2\u4f53\u4e2d\u4f46\u672a\u914d\u5236\u6210\u7eb3\u7c73\u9897\u7c92\u7684\u76f8\u540c\u836f\u7269\u76f8\u6bd4\uff0c\u6240\u6709\u4e09\u79cd\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\u5747\u8868\u73b0\u51fa\u957f\u6548\u7279\u6027\u3002\u5355\u6b21\u6ce8\u5c04\u540e\uff0c\u8840\u6d46\u4e2d\u7684\u836f\u7269\u6d53\u5ea6\u7ef4\u6301\u5728\u9ad8\u4e8e\u9884\u6d4b\u6709\u6548\u6d53\u5ea6\u7684\u56db\u4e2a\u661f\u671f\u5185\u3002\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u7ec6\u80de\u4e2d\u7684\u836f\u7269\u66b4\u9732\u6c34\u5e73\u751a\u81f3\u9ad8\u4e8e\u8840\u6d46\u4e2d\u7684\u6c34\u5e73\uff0c\u8fd9\u8868\u660e\u7ec6\u80de\u9776\u5411\u836f\u7269\u7ec4\u5408\u8f93\u9001\u3002<\/p>\n<p>\u66ff\u8bfa\u798f\u97e6\u548c\u62c9\u7c73\u592b\u5b9a\u8fd8\u5177\u6709\u6297\u4e59\u578b\u809d\u708e\u75c5\u6bd2 (HBV) \u7684\u6d3b\u6027\uff0c\u56e0\u6b64\u8be5\u7597\u6cd5\u9002\u5408 HIV\/HBV 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