{"id":2507,"date":"2024-03-02T16:35:51","date_gmt":"2024-03-02T08:35:51","guid":{"rendered":"http:\/\/baijianyy.cn\/?p=2507"},"modified":"2024-03-02T16:35:51","modified_gmt":"2024-03-02T08:35:51","slug":"%e6%ad%a6%e6%b1%89%e5%b8%82%e8%94%a1%e7%94%b8%e5%8c%ba%e4%ba%8b%e5%89%8d%e9%98%bb%e6%96%ad%e8%8d%af%ef%bc%9f%e6%a8%a1%e5%9e%8b%e7%a0%94%e7%a9%b6%e5%be%97%e5%87%ba%e7%bb%93%e8%ae%ba%ef%bc%8c%e5%8f%a3","status":"publish","type":"post","link":"http:\/\/baijianyy.cn\/?p=2507","title":{"rendered":"\u6b66\u6c49\u5e02\u8521\u7538\u533a\u4e8b\u524d\u963b\u65ad\u836f\uff1f\u6a21\u578b\u7814\u7a76\u5f97\u51fa\u7ed3\u8bba\uff0c\u53e3\u670dHIV\u66b4\u9732\u524d\u9884\u9632\u836f\u7269\u5bf9\u5973\u6027\u548c\u7537\u6027\u540c\u6837\u6709\u6548"},"content":{"rendered":"<p>\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54c1\u9500\u552e\u673a\u6784\uff1f<br \/>\npep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u3001prep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u5168\u56fd\u4e24\u5c0f\u65f6\u6025\u9001\uff0c\u836f\u5e97\u76f4\u53d1\uff0c\u4e13\u4eba\u4e13\u9001<\/p>\n<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85\" target=\"_blank\" rel=\"noopener\">\u827e\u6ecb\u75c5<\/a>HIV\u66b4\u9732\u524d\u540e\u963b\u65ad\u9884\u9632\u7528\u836f\uff0c\u8bf7\u626b\u7801\u6dfb\u52a0\u533b\u9662\u5ba2\u670d\uff0c<strong>\u5168\u56fd\u5404\u57ce\u5e02<\/strong>\u6700\u5feb2\u5c0f\u65f6\u5de6\u53f3\u9001\u8fbe\u3002<\/p>\n<p>\u9ad8\u5371\u884c\u4e3a\u540e\u591a\u4e45\u68c0\u6d4b\uff1f\u9ad8\u5371\u6027\u884c\u4e3a\u4e00\u6b21\u8981\u5403<a href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">\u963b\u65ad\u836f<\/a>\u5417\uff1f\u53d1\u751f\u9ad8\u5371\u6027\u884c\u4e3a\u540e\u600e\u4e48\u529e\uff1f\u9ad8\u5371\u884c\u4e3a\u591a\u5c11\u5929\u540e\u53ef\u4ee5\u5f7b\u5e95\u6392\u9664\uff1f\u7b49\u7b49\u95ee\u9898\uff0c\u53ef\u4ee5\u5728\u4e92\u8054\u7f51\u533b\u9662\u514d\u8d39\u54a8\u8be2\u4e13\u4e1a\u611f\u67d3\u79d1\u533b\u5e08\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-127 aligncenter\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/mmexport1702183130138.gif\" alt=\"\" width=\"300\" height=\"300\" \/><\/p>\n<p>\u6b66\u6c49\u5e02\u8521\u7538\u533a\u81ea\u613f\u54a8\u8be2\u68c0\u6d4b\u673a\u6784\uff1a \u6b66\u6c49\u5e02\u8521\u7538\u533a\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3<\/p>\n<p>\u5730\u5740\uff1a \u6b66\u6c49\u5e02\u8521\u7538\u533a\u8521\u7538\u8857\u6210\u529f\u5927\u9053111\u53f7<\/p>\n<p>\u4e8b\u524d\u963b\u65ad\u836f\uff1f\u6b64\u95ee\u9898\u8bf7\u626b\u4e0a\u9762\u7684\u7801\u5173\u6ce8\u4e92\u8054\u7f51\u533b\u9662\uff0c\u4e3a\u60a8\u89e3\u7b54<\/p>\n<hr \/>\n<p>\u6bcf\u5468 4 \u5242 PrEP(<a href=\"http:\/\/baijianyy.cn\/?tag=hiv%e6%9a%b4%e9%9c%b2%e5%89%8d%e9%a2%84%e9%98%b2\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201cHIV\u66b4\u9732\u524d\u9884\u9632\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">HIV\u66b4\u9732\u524d\u9884\u9632<\/a>) \u53ef\u80fd\u8db3\u4ee5\u8fbe\u5230 95-100% \u7684\u529f\u6548\u3002<\/p>\n<p>\u5bf9 PrEP \u529f\u6548\u8bd5\u9a8c\u6570\u636e\u7684\u4e24\u9879\u91cd\u65b0\u5206\u6790\u5f97\u51fa\u7ed3\u8bba\uff0c\u5bf9\u4e8e\u901a\u8fc7\u9634\u9053\u6027\u4ea4\u63a5\u89e6 HIV \u7684\u4eba\u6765\u8bf4\uff0c\u53e3\u670d PrEP \u4e0e\u901a\u8fc7\u809b\u4ea4\u63a5\u89e6 HIV \u7684\u4eba\u4e00\u6837\u6709\u6548\u3002\u987a\u6027\u522b\u5973\u6027\u7684\u7597\u6548\u8f83\u4f4e\uff0c\u5e76\u4e14\u5728\u4e00\u4e9b\u5927\u578b\u8bd5\u9a8c\u4e2d\u7597\u6548\u4e3a\u96f6\uff0c\u8fd9\u51e0\u4e4e\u5b8c\u5168\u662f\u7531\u4e8e\u4f9d\u4ece\u6027\u7684\u5dee\u5f02\uff0c\u800c\u4e0d\u662f\u7531\u4e8e\u5973\u6027\u8eab\u4f53\u6216\u9634\u9053\u800c\u4e0d\u662f\u76f4\u80a0\u7ec4\u7ec7\u5438\u6536 PrEP \u7684\u65b9\u5f0f\u5b58\u5728\u4efb\u4f55\u751f\u7269\u5b66\u5dee\u5f02\u3002\u7279\u522b\u662f\uff0c\u7814\u7a76\u8868\u660e\uff0c\u6bcf\u5468 4 \u5242\u6216\u66f4\u591a\u5242\u91cf\u7684 PrEP \u5177\u6709 95-100% \u7684\u7597\u6548\uff0c\u5c31\u50cf\u5bf9\u7537\u540c\u6027\u604b\u8005\u6240\u505a\u7684\u90a3\u6837\u3002<\/p>\n<p>\u5176\u4e2d\u4e00\u9879\u5206\u6790\u6765\u81ea\u827e\u6ecb\u75c5\u6bd2\u9884\u9632\u8bd5\u9a8c\u7f51\u7edc (HPTN) \u7684 Mia Moore \u535a\u58eb\u53ca\u5176\u540c\u4e8b\uff0c\u53e6\u4e00\u9879\u5206\u6790\u5219\u6765\u81ea\u67cf\u6797\u7f57\u4f2f\u7279\u79d1\u8d6b\u7814\u7a76\u6240\u7684 Lanxin \u5f20\u53ca\u5176\u540c\u4e8b\u3002\u8fd9\u4e24\u7bc7\u8bba\u6587\u5747\u53d1\u8868\u5728\u300a\u81ea\u7136\u533b\u5b66\u300b11 \u6708\u53f7\u4e0a\u3002<\/p>\n<p>\u80cc\u666f<\/p>\n<p>PrEP \u5173\u952e\u529f\u6548\u7814\u7a76\u7684\u5341\u5e74\u6570\u636e\u4ee4\u4eba\u4fe1\u670d\u5730\u8bc1\u660e\uff0c\u4f7f\u7528\u66ff\u8bfa\u798f\u97e6\u4e8c\u5421\u544b\u916f (TDF) \u52a0\u6069\u66f2\u4ed6\u6ee8 (FTC) \u7684\u53e3\u670d PrEP \u53ef\u9884\u9632\u66b4\u9732\u4e8e\u75c5\u6bd2\u7684\u7537\u540c\u6027\u604b\u548c\u53cc\u6027\u604b\u7537\u6027\u4e2d\u7684\u5927\u591a\u6570 HIV \u611f\u67d3\u3002\u6700\u521d\uff0cPrEP \u7684\u6548\u679c\u4f3c\u4e4e\u76f8\u5f53\u6709\u9650\uff0c\u5728 2010 \u5e74\u5f00\u521b\u6027\u7684iPrEx \u7814\u7a76\u4e2d\uff0c\u670d\u7528 TDF\/FTC \u7684\u7537\u6027\u4e0e\u670d\u7528\u5b89\u6170\u5242\u7684\u7537\u6027\u76f8\u6bd4\uff0c\u827e\u6ecb\u75c5\u6bd2\u611f\u67d3\u7387\u4ec5\u964d\u4f4e\u4e86 44% \u3002\u4f46\u5373\u4fbf\u5982\u6b64\uff0c\u62a5\u544a\u670d\u7528\u6240\u6709\u836f\u7269\u7684\u7537\u6027\u7684\u7597\u6548\u4ecd\u4e3a 73%\uff0c\u7814\u7a76\u4eba\u5458\u4f30\u8ba1\uff0c\u6839\u636e\u8840\u6db2\u4e2d\u7684\u836f\u7269\u6d53\u5ea6\u6d4b\u91cf\uff0c\u5b9e\u9645\u4e0a\u670d\u7528\u6240\u6709\u836f\u7269\u7684\u7537\u6027\u7684\u7597\u6548\u9ad8\u8fbe 92 %\u3002<\/p>\n<p>\u4e24\u9879\u9488\u5bf9\u5f02\u6027\u604b\u7537\u6027\u548c\u5973\u6027\u7684\u65e9\u671f\u7814\u7a76\u4f3c\u4e4e\u4e5f\u5f88\u6709\u5e0c\u671b\u3002\u5728\u9488\u5bf9\u975e\u6d32\u5f02\u6027\u604b\u592b\u5987\u7684Partners PrEP \u7814\u7a76\u4e2d\uff0c\u5973\u6027\u7684\u6709\u6548\u6027\u4e3a 63%\uff0c\u7537\u6027\u7684\u6709\u6548\u6027\u4e3a 83%\uff0c\u800c\u5728\u535a\u8328\u74e6\u7eb3\u4e3b\u8981\u9488\u5bf9\u5e74\u8f7b\u5f02\u6027\u604b\u8005\u7684 TDF2 \u7814\u7a76\u4e2d\uff0c\u5973\u6027\uff08\u5728\u90a3\u4e9b\u8fd4\u56de\u5904\u65b9\u836f\u7684\u4eba\u4e2d\uff09\u7684\u6709\u6548\u6027\u4e3a 75.5%\uff0c\u7537\u6027\u4e3a 83% \u3002\uff08\u8fd9\u4e24\u9879 2011 \u5e74\u7684\u968f\u673a\u7814\u7a76\u4ecd\u7136\u662f\u6211\u4eec\u8bc1\u660e PrEP \u5bf9\u5f02\u6027\u604b\u7537\u6027\u6709\u6548\u7684\u552f\u4e00\u8bc1\u636e\u3002\uff09<\/p>\n<p>\u4f46\u4e24\u9879\u9488\u5bf9\u5973\u6027\u7684\u5927\u578b\u7814\u7a76\u5374\u4ee4\u4eba\u9707\u60ca\u3002FEM-PrEP \u7814\u7a76\u53d1\u73b0\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u63a5\u53d7 PrEP \u7684\u5973\u6027\u7684 HIV \u611f\u67d3\u7387\u4ec5\u51cf\u5c11\u4e86 6%\uff0c\u800c2013 \u5e74\u7684 VOICE \u7814\u7a76\u5b9e\u9645\u4e0a\u53d1\u73b0\uff0c\u63a5\u53d7 PrEP \u7684\u5973\u6027\u7684\u827e\u6ecb\u75c5\u6bd2\u611f\u67d3\u7387\u589e\u52a0\u4e86 4.4%\u3002\u8fd9\u4e24\u4e2a\u7ed3\u679c\u5728\u7edf\u8ba1\u4e0a\u76f8\u5f53\u4e8e\u96f6\u6709\u6548\u6027\u3002<\/p>\n<p>Aidsmap \u5f53\u65f6\u8bc4\u8bba\u8bf4 VOICE \u7684\u7ed3\u679c\u201c\u5bf9 PrEP \u63d0\u51fa\u4e86\u91cd\u5927\u95ee\u9898\u201d\u30022015 \u5e74\uff0c\u8fd9\u4e9b\u95ee\u9898\u5728\u7537\u540c\u6027\u604b\u8eab\u4e0a\u5f97\u5230\u4e86\u89e3\u7b54\uff0c\u5f53\u65f6PROUD\u548cIPERGAY \u7814\u7a76\u5747\u62a5\u544a\u79f0\uff0cPrEP \u7684\u6709\u6548\u7387\u4e3a 86%\uff0c\u5373\u4f7f\u50cf IPERGAY \u90a3\u6837\uff0c\u662f\u6839\u636e\u4e8b\u4ef6\u5242\u91cf\u800c\u4e0d\u662f\u6bcf\u5929\u670d\u7528\u3002<\/p>\n<p>\u5f53\u65f6\u4f3c\u4e4e\u5f88\u6e05\u695a\uff0cFEM-PrEP \u548c VOICE \u7684\u8d1f\u9762\u7ed3\u679c\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u7531\u4e8e\u4f9d\u4ece\u6027\u5dee\uff0c\u800c\u8fd9\u4e3b\u8981\u662f\u7531\u4e8e\u53c2\u4e0e\u8005\u5bf9 PrEP \u548c\u7814\u7a76\u8fc7\u7a0b\u7684\u4e0d\u4fe1\u4efb\u9020\u6210\u7684\u3002\u4f46\u4e5f\u6709\u4eba\u8d28\u7591\uff0cPrEP \u672c\u8d28\u4e0a\u5bf9\u4e8e\u9634\u9053\u6027\u4ea4\u800c\u4e0d\u662f\u809b\u4ea4\u7684\u66b4\u9732\u6548\u679c\u662f\u5426\u8f83\u5dee\u3002<\/p>\n<p>\u4e00\u4e9b\u7ed3\u679c\u4f3c\u4e4e\u8868\u660e\uff0c\u867d\u7136\u6bcf\u5468\u9002\u5ea6\u575a\u6301\u670d\u7528 3-4 \u7c92\u836f\u4e38\u5c31\u8db3\u4ee5\u963b\u6b62\u809b\u4ea4\u611f\u67d3\u827e\u6ecb\u75c5\u6bd2\uff0c\u4f46\u9634\u9053\u6027\u4ea4\u5219\u9700\u8981\u6bcf\u5468\u670d\u7528 6-7 \u7c92\u836f\u4e38\u624d\u80fd\u53d1\u6325\u4f5c\u7528\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u4e0e\u76f4\u80a0\u7ec4\u7ec7\u76f8\u6bd4\uff0c\u66ff\u8bfa\u798f\u97e6\uff08\u4f46\u4e0d\u662f\u6069\u66f2\u4ed6\u6ee8\uff09\u9700\u8981\u66f4\u957f\u7684\u65f6\u95f4\u624d\u80fd\u8fbe\u5230\u9634\u9053\u7ec4\u7ec7\u4e2d\u7684\u9884\u9632\u6c34\u5e73\uff0c\u5e76\u4e14\u6c38\u8fdc\u4e0d\u4f1a\u8fbe\u5230\u76f8\u540c\u7684\u6c34\u5e73\u3002\u8fd9\u662f\u5426\u53ef\u4ee5\u89e3\u91ca\u5973\u6027\u7597\u6548\u8f83\u5dee\u7684\u539f\u56e0\uff1f<\/p>\n<p>\u52a8\u7269\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u53ef\u80fd\u4e0e\u9634\u9053\u7ec6\u80de\u542b\u6709\u8f83\u9ad8\u6c34\u5e73\u7684\u5929\u7136\u6838\u82f7\u6709\u5173\uff0c\u8fd9\u4e9b\u6838\u82f7\u4e0e PrEP \u4e2d\u4f7f\u7528\u7684\u57fa\u4e8e\u6838\u82f7\u7684 NRTI \u836f\u7269\u7ade\u4e89\uff0c\u5e76\u4f18\u5148\u63ba\u5165\u75c5\u6bd2\u6210\u5206\u4e2d\u3002\u6b64\u5916\uff0c\u4e00\u4e9b\u7814\u7a76\u8868\u660e\u7ec6\u83cc\u6027\u9634\u9053\u75c5\u53ef\u80fd\u4f1a\u5f71\u54cd PrEP \u7684\u7597\u6548\u3002<\/p>\n<p>\u6240\u6709\u8fd9\u4e9b\u4e0d\u4ec5\u6392\u9664\u4e86\u5973\u6027\u56e0\u4e8b\u4ef6\u9a71\u52a8\u7684 PrEP\uff0c\u800c\u4e14\u8fd8\u53ef\u80fd\u610f\u5473\u7740\u5979\u4eec\u7684 PrEP \u901a\u5e38\u5bf9\u9519\u8fc7\u5242\u91cf\u7684\u5bb9\u5fcd\u5ea6\u8f83\u4f4e\u3002<\/p>\n<p>HPTN 084 \u5bf9\u6ce8\u5c04\u578b PrEP \u7814\u7a76\u7684\u6781\u5176\u79ef\u6781\u7684\u7ed3\u679c\u63a8\u7ffb\u4e86 PrEP \u4e00\u822c\u5bf9\u5973\u6027\u6548\u679c\u8f83\u5dee\u7684\u89c2\u70b9\uff0c\u4f46\u7531\u4e8e HPTN 084 \u5c06\u6ce8\u5c04\u578b\u5361\u535a\u7279\u97e6\u4e0e TDF\/FTC \u800c\u4e0d\u662f\u4e0e\u5b89\u6170\u5242\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u56e0\u6b64\u7559\u4e0b\u4e86\u4e00\u4e2a\u60ac\u800c\u672a\u51b3\u7684\u95ee\u9898\uff1a\u8fd9\u4e9b\u836f\u7269\u662f\u5426\u672c\u8d28\u4e0a\u5bf9\u5973\u6027\u7597\u6548\u8f83\u5dee\u3002<\/p>\n<p>\u8ba1\u7b97\u5973\u6027\u7684\u751f\u7269\u5b66\u529f\u6548<\/p>\n<p>\u6211\u4eec\u77e5\u9053\u540c\u6027\u604b\u548c\u53cc\u6027\u604b\u7537\u6027\u4f53\u5185\u7684 PrEP \u836f\u7269\u6c34\u5e73\u8db3\u4ee5\u9884\u9632 HIV \u611f\u67d3\u3002\u8fd9\u662f\u56e0\u4e3a\u5341\u5e74\u524d\uff0c\u7814\u7a76\u4eba\u5458\u80fd\u591f\u6839\u636e PrEP \u529f\u6548\u7814\u7a76\u7684\u7ed3\u679c\uff08\u5c06\u8fd9\u4e9b\u6c34\u5e73\u4e0e\u5934\u53d1\u4e2d\u6d4b\u91cf\u7684\u957f\u671f\u836f\u7269\u6c34\u5e73\u76f8\u5173\u8054\uff09\u6765\u6821\u51c6STRAND \u7814\u7a76\u7684\u7ed3\u679c\uff08\u5c06\u5242\u91cf\u9891\u7387\u4e0e\u5934\u53d1\u4e2d\u6d4b\u91cf\u7684\u957f\u671f\u836f\u7269\u6c34\u5e73\u76f8\u5173\u8054\uff09\u3002\u89c2\u5bdf\u5230\u7684\u827e\u6ecb\u75c5\u6bd2\u611f\u67d3\u4eba\u6570\u3002\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>\u5934\u53d1\u6216\u5e72\u8840\u6591 (DBS) \u7b49\u7ec6\u80de\u6837\u672c\u4e2d\u7684\u6c34\u5e73\u66f4\u53ef\u9760\uff0c\u56e0\u4e3a\u5b83\u4eec\u63d0\u4f9b\u4e86\u6570\u5468\u751a\u81f3\u6570\u6708\u5185\u957f\u671f\u3001\u4e00\u81f4\u4f7f\u7528\u7684\u8bc1\u636e\uff0c\u800c\u8840\u6d46\u6c34\u5e73\u4ec5\u663e\u793a\u6700\u540e\u51e0\u5929\u7684\u575a\u6301\u60c5\u51b5\uff0c\u5e76\u4e14\u662f\u5bb9\u6613\u53d7\u5230\u8bf8\u5982\u201c\u767d\u5927\u8902\u7ed9\u836f\u201d\uff08\u4eba\u4eec\u5728\u8981\u68c0\u67e5\u5176\u4f9d\u4ece\u6027\u4e4b\u524d\u6062\u590d\u6cbb\u7597\uff09\u7b49\u73b0\u8c61\u7684\u5f71\u54cd\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u5728\u5973\u6027\u4e2d\uff0c\u6ca1\u6709\u4e0e STRAND \u76f8\u5f53\u7684\u7269\u8d28\uff0c\u5982\u679c\u7531\u4e8e\u9634\u9053\u7ec4\u7ec7\u4e2d\u7684\u836f\u7269\u6c34\u5e73\u8f83\u4f4e\uff0c\u8840\u6d46\u6216\u7ec6\u80de\u5185 DBS \u6c34\u5e73\u4e0d\u80fd\u53ef\u9760\u5730\u9884\u6d4b\u7597\u6548\uff0c\u5219\u8fd9\u4e00\u70b9\u5c24\u5176\u91cd\u8981\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4f46\u4e00\u7bc7\u8bba\u6587\uff08Moore \u7b49\u4eba\uff09\u7684\u4f5c\u8005\u610f\u8bc6\u5230HPTN 082\u7684\u5f62\u72b6\u51e0\u4e4e\u76f8\u540c\u3002\u8fd9\u4e3b\u8981\u662f\u4e00\u9879\u7814\u7a76\uff0c\u65e8\u5728\u4e86\u89e3\u9752\u5e74\u53cb\u597d\u7684\u5370\u5237\u5a92\u4f53\u3001\u89c6\u9891\u3001\u793e\u533a\u54a8\u8be2\u548c\u5176\u4ed6\u53c2\u4e0e\u6d3b\u52a8\u662f\u5426\u9f13\u52b1\u5c11\u5973\u548c\u5e74\u8f7b\u5973\u6027\u91c7\u7528\u548c\u575a\u6301 PrEP\u3002\u8fd9\u6b21\u6d3b\u52a8\u53d6\u5f97\u4e86\u6210\u529f\uff0c\u53c2\u4e0e\u8005\u7684\u9075\u5b88\u7387\u9ad8\u8fbe 95%\u3002\u4f46 Moore \u7b49\u4eba\u8bba\u6587\u7684\u91cd\u8981\u56e0\u7d20\u662f\uff0c\u5b83\u6d4b\u91cf\u4e86 DBS \u6837\u672c\u4e2d\u7684\u957f\u671f\u836f\u7269\u6c34\u5e73\u548c\u8840\u6d46\u4e2d\u7684\u77ed\u671f\u836f\u7269\u6c34\u5e73\u3002\u8fd9\u4f7f\u5f97\u7814\u7a76\u4eba\u5458\u80fd\u591f\u5728 HPTN 082 \u4e2d\u6d4b\u91cf\u7684\u7ec6\u80de\u5185\u6c34\u5e73\u4e0e\u65e9\u671f\u529f\u6548\u7814\u7a76\u4e2d\u6d4b\u91cf\u7684\u8840\u6d46\u6c34\u5e73\u4e4b\u95f4\u5efa\u7acb\u76f8\u5173\u6027\u3002\u7136\u540e\uff0c\u81f3\u5173\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u4eec\u53ef\u4ee5\u5c06\u5176\u4e0e\u836f\u7269\u6c34\u5e73\u4f4e\u548c\u9ad8\u7684\u5973\u6027\u7684\u827e\u6ecb\u75c5\u6bd2\u53d1\u75c5\u7387\u8054\u7cfb\u8d77\u6765\uff0c\u5e76\u786e\u5b9a\u4e0d\u540c\u6c34\u5e73\u63d0\u4f9b\u7684\u4fdd\u62a4\u7a0b\u5ea6\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u7531\u4e8e\u5728 FEM-PrEP \u548c VOICE \u4e2d\u5b8c\u5168\u4f9d\u4ece\u6027\u975e\u5e38\u7f55\u89c1\uff0c\u56e0\u6b64\u4ed6\u4eec\u65e0\u6cd5\u4f7f\u7528\u8fd9\u4e9b\u7814\u7a76\u7684\u6570\u636e\uff0c\u4f46\u4ed6\u4eec\u53ef\u4ee5\u4f7f\u7528\u5728 Partners PrEP \u4e2d\u6d4b\u91cf\u7684\u836f\u7269\u6c34\u5e73\u4ee5\u53ca\u5728\u8f83\u5c0f\u7a0b\u5ea6\u4e0a\u5728 TDF2 \u4e2d\u6d4b\u91cf\u7684\u836f\u7269\u6c34\u5e73\u3002\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u4eec\u73b0\u5728\u8fd8\u53ef\u4ee5\u786e\u5b9a HPTN 084 \u4e2d\u5206\u914d\u7ed9\u8be5\u836f\u7269\u7684\u5973\u6027\u7684\u751f\u7269\u529f\u6548\u6216 TDF\/FTC\uff0c\u5373\u4f7f\u6ca1\u6709\u5b89\u6170\u5242\u53ef\u4ee5\u4e0e\u4e4b\u6bd4\u8f83\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u5c31 HPTN 084 \u800c\u8a00\uff0c\u670d\u7528 TDF\/FTC \u7684\u5973\u6027\u7684 HIV \u53d1\u75c5\u7387\u4ec5\u6bd4 VOICE \u7814\u7a76\u4e2d\u5b89\u6170\u5242\u7ec4\u7684\u5973\u6027\u4f4e 15%\uff08\u7ecf\u8fc7\u8c03\u6574\u4ee5\u53cd\u6620\u4e24\u4e2a\u7814\u7a76\u7ec4\u7684\u4e0d\u540c\u7ec4\u6210\uff09\u3002\u8fd9\u770b\u8d77\u6765\u4f3c\u4e4e\u662f\u7531\u4e8e\u4f9d\u4ece\u6027\u5dee\u9020\u6210\u7684\u2014\u2014HPTN 084 \u4e2d\u91c7\u96c6\u7684\u6240\u6709\u6837\u672c\u4e2d\u6709 44% \u5728\u5206\u914d\u7ed9 TDF\/FTC \u7684\u5973\u6027\u4e2d\u672a\u53d1\u73b0\u53ef\u68c0\u6d4b\u5230\u7684\u836f\u7269\u3002\u4f46\u5728\u8fdb\u884c\u4ed4\u7ec6\u6bd4\u8f83\u4e4b\u524d\uff0c\u6ca1\u6709\u4eba\u80fd\u8bf4\u51fa\u751f\u7269\u8fc7\u7a0b\u7684\u8d21\u732e\u7a0b\u5ea6\u3002<\/p>\n<p>Moore \u7b49\u4eba\u7684\u5e95\u7ebf\u53d1\u73b0\u662f\uff0c\u575a\u6301\u6bcf\u5468\u670d\u7528\u4e24\u7247\u836f\u4e38\uff0c\u6297 HIV \u7684\u5e73\u5747\u529f\u6548\u5e94\u4e3a 58%\uff1b\u6bcf\u5468\u56db\u7c92\u836f\u5e94\u6709 84% \u7684\u7597\u6548\uff1b\u6bcf\u5468\u670d\u7528 7 \u7c92\u836f\u4e38\u5e94\u80fd\u63d0\u4f9b 96% \u7684\u7597\u6548\u3002<\/p>\n<p>\u8fd9\u4ecd\u7136\u4f4e\u4e8e\u9488\u5bf9\u7537\u540c\u6027\u604b\u548c\u53cc\u6027\u604b\u7537\u6027\u8ba1\u7b97\u7684\u529f\u6548\uff0c\u5e76\u4e14\u4e0e\u53bb\u5e74 1 \u6708\u53d1\u5e03\u7684 HPTN 084 \u7684\u53e6\u4e00\u9879\u5206\u6790\u8ba1\u7b97\u7684\u7ed3\u679c\u5927\u81f4\u76f8\u540c\u3002<\/p>\n<p>\u7136\u800c\uff0c\u7b2c\u4e8c\u9879\u7814\u7a76\uff08Zhang\uff09\u8868\u660e\uff0c\u8fd9\u4e9b\u53ef\u80fd\u4ecd\u7136\u4f4e\u4f30\u4e86\u4e0d\u540c\u5242\u91cf\u53e3\u670d PrEP \u5bf9\u5973\u6027\u7684\u751f\u7269\u5b66\u529f\u6548\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u8fd9\u9879\u7814\u7a76\u8fd8\u4f7f\u7528\u6240\u8c13\u7684\u201c\u81ea\u4e0a\u800c\u4e0b\u201d\u65b9\u6cd5\u6765\u8ba1\u7b97\u53e3\u670d PrEP \u7684\u529f\u6548\uff0c\u5176\u57fa\u7840\u662f\u836f\u7269\u6c34\u5e73\u4e0e HPTN 084\u3001Partners PrEP \u4ee5\u53ca\u8f83\u5c0f\u7a0b\u5ea6\u4e0a TDF2 \u4e2d\u68c0\u6d4b\u5230\u7684\u529f\u6548\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002\u7136\u800c\uff0c\u4ed6\u4eec\u5e76\u6ca1\u6709\u5c1d\u8bd5\u5c06\u6bcf\u5468\u4e0d\u540c\u7684\u5242\u91cf\u4e0e\u4e0d\u540c\u7684\u529f\u6548\u8054\u7cfb\u8d77\u6765\uff0c\u800c\u53ea\u662f\u5c06\u7814\u7a76\u53c2\u4e0e\u8005\u5206\u4e3a\u201c\u672a\u68c0\u6d4b\u5230\u836f\u7269\u201d\uff08\u8fd9\u610f\u5473\u7740\u529f\u6548\u4e3a\u96f6\uff09\u548c\u201c\u68c0\u6d4b\u5230\u4e00\u4e9b\u836f\u7269\u201d\uff08\u8fd9\u610f\u5473\u7740\u529f\u6548\u5728 90% \u81f3 100% \u8303\u56f4\u5185\uff09\u3002\u8fd9\u4e9b\u4e0d\u662f\u731c\u6d4b\uff0c\u800c\u662f\u57fa\u4e8e\u5bf9\u4e09\u9879\u7814\u7a76\u4e2d\u7684\u575a\u6301\u7597\u6548\u66f2\u7ebf\u7684\u5206\u6790\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u6bcf\u5468\u670d\u7528\u4e24\u7247\u5de6\u53f3\u7684\u836f\u7247\u65f6\uff0c\u7597\u6548\u6025\u5267\u4e0b\u964d\uff1a\u5728\u836f\u7269\u6c34\u5e73\u8868\u660e\u670d\u7528\u4e24\u7247\u6216\u66f4\u591a\u836f\u7247\u7684\u5973\u6027\u4e2d\uff0c\u5f88\u5c11\u53d1\u73b0\u611f\u67d3\uff0c\u4f46\u4efb\u4f55\u4f4e\u4e8e\u8be5\u6c34\u5e73\u7684\u6c34\u5e73\u4e0e\u7edf\u8ba1\u4e0a\u4e3a\u96f6\u7684\u7597\u6548\u76f8\u5173\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6469\u5c14\u7b49\u4eba\u3002\u5728\u4ed6\u4eec\u7684\u8bba\u6587\u4e2d\u8bc4\u8bba\u8bf4\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5ffd\u7565\u4e86\u90e8\u5206\u4f9d\u4ece\u6027\u63d0\u4f9b\u7684\u90e8\u5206\u529f\u6548\uff0c\u4f46\u8fd9\u53ea\u662fZhang\u7b49\u4eba\u4f7f\u7528\u7684\u6a21\u578b\u7684\u4e00\u90e8\u5206\u3002\u7136\u540e\uff0c\u4ed6\u4eec\u6839\u636e\u201c\u81ea\u4e0a\u800c\u4e0b\u201d\u7684\u6570\u636e\uff0c\u901a\u8fc7\u6839\u636e\u201c\u81ea\u4e0b\u800c\u4e0a\u201d\u65b9\u6cd5\u63d0\u4f9b\u7684 PrEP \u529f\u6548\u9884\u6d4b\u8fdb\u884c\u6821\u51c6\uff0c\u6d4b\u8bd5\u4e86\u8fd9\u4e2a 90-100% \u529f\u6548\u6570\u5b57\u7684\u53ef\u9760\u6027\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u8fd9\u79cd\u65b9\u6cd5\u4f7f\u7528\u6240\u8c13\u7684\u53cd\u4e8b\u5b9e\u573a\u666f\u3002\u7814\u7a76\u4eba\u5458\u6d4b\u8bd5\u4e86\u5bf9\u5973\u6027 PrEP \u4e2d\u53e3\u670d\u836f\u7269\u6709\u6548\u6027\u8f83\u4f4e\u7684\u4e0d\u540c\u89e3\u91ca\uff0c\u4ed6\u4eec\u63d0\u51fa\u4ee5\u4e0b\u95ee\u9898\uff1a\u201c\u5982\u679c\u9634\u9053\u7ec4\u7ec7\u4e2d\u8f83\u4f4e\u7684\u836f\u7269\u6c34\u5e73\u662f\u7597\u6548\u7684\u6700\u91cd\u8981\u51b3\u5b9a\u56e0\u7d20\uff0c\u90a3\u4e48\u6211\u4eec\u671f\u671b PrEP \u7684\u7597\u6548\u5982\u4f55\uff1f\u5982\u679c\u7ec6\u80de\u4e2d\u7ade\u4e89\u5bbf\u4e3b\u6838\u82f7\u7684\u6c34\u5e73\u663e\u7740\u600e\u4e48\u529e\uff1fPrEP 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95%\u3002\u4f46\u662f\uff0c\u5982\u679c\u9634\u9053\u548c\u5bab\u9888\u7ec4\u7ec7\u4e2d\u8f83\u4f4e\u7684\u836f\u7269\u6c34\u5e73\u662f PrEP \u7597\u6548\u7684\u4e3b\u8981\u51b3\u5b9a\u56e0\u7d20\uff0c\u90a3\u4e48\u6211\u4eec\u5b9e\u9645\u770b\u5230\u7684\u6709\u6548\u6027\u5c06\u4f1a\u4f4e\u5f97\u591a\uff0c\u6bcf\u5468 7 \u5242\u7684\u7597\u6548\u4ec5\u4e3a 50%\uff0c\u6bcf\u5468 2 \u5242\u7684\u7597\u6548\u4ec5\u4e3a 20%\u3002 \u5982\u679c\u5c06\u5bbf\u4e3b\u6838\u82f7\u548c\u4e00\u5b9a\u6bd4\u4f8b\u7684\u809b\u4ea4\u7684\u6548\u679c\u52a0\u5728\u4e00\u8d77\uff0c\u6bcf\u5468 7 \u5242\u7684\u529f\u6548\u4f1a\u6709\u6240\u589e\u52a0\u5230 75% \u4ee5\u4e0a\uff0c\u6bcf\u5468 2 \u5242\u7684\u529f\u6548\u4f1a\u589e\u52a0\u5230 55%\uff0c\u4f46\u4ecd\u7136\u6bd4\u7814\u7a76\u4eba\u5458\u5efa\u8bae\u7684\u6570\u636e\u4f4e\u5f97\u591a\u3002\u8bd5\u9a8c\u3002\u5f20\u7b49\u4eba\u8ba1\u7b97\u7684\u5e95\u7ebf\u6570\u5b57\u3002\u6bcf\u5468\u6ce8\u5c04\u56db\u5242\u6216\u66f4\u591a\u5242\u91cf\u63a5\u8fd1 100% \u6709\u6548\u2014\u2014\u4e0e\u540c\u6027\u604b\u548c\u53cc\u6027\u604b\u7537\u6027\u7684\u6548\u679c\u5b8c\u5168\u4e00\u6837\u3002<\/p>\n<p>\u4e3a\u4e86\u8fdb\u4e00\u6b65\u8bf4\u660e\u8fd9\u4e00\u70b9\uff1a\u4ed6\u4eec\u7684\u6a21\u578b\u8ba1\u7b97\u51fa\uff0c\u5bf9\u4e8e\u8840\u6db2\u4e2d\u53ef\u68c0\u6d4b\u5230\u4efb\u4f55\u836f\u7269\u6c34\u5e73\u7684\u5973\u6027\uff0c\u5982\u679c\u6dcb\u5df4\u7ec6\u80de\u4e2d\u7684\u836f\u7269\u6c34\u5e73\u662f\u7597\u6548\u7684\u6700\u91cd\u8981\u51b3\u5b9a\u56e0\u7d20\uff0c\u5219\u9884\u8ba1 HPTN 084 \u4e2d\u4f1a\u51fa\u73b0\u4e09\u5230\u56db\u4f8b HIV \u611f\u67d3\u3002\u7136\u800c\uff0c\u5982\u679c\u9634\u9053\u7ec4\u7ec7\u4e2d\u7684\u836f\u7269\u6c34\u5e73\u81f3\u5173\u91cd\u8981\uff0c\u90a3\u4e48\u9884\u8ba1\u4f1a\u51fa\u73b0 15 \u81f3 27 \u4f8b HIV \u611f\u67d3\u3002<\/p>\n<p>\u524d\u8005\u662f\u4e8b\u5b9e\u771f\u76f8\uff1a\u5728 HPTN 084 \u4e2d\u5206\u914d\u5230 TDF\/FTC \u7684\u5973\u6027\u4e2d\u53d1\u73b0\u7684 36 \u4f8b HIV \u611f\u67d3\u4e2d\uff0c\u53ea\u6709 4 \u4f8b\u7684\u5973\u6027\u8840\u6d46\u4e2d\u6839\u672c\u68c0\u6d4b\u4e0d\u5230\u4efb\u4f55\u836f\u7269\u3002<\/p>\n<p>\u7814\u7a76\u53d1\u73b0\uff1a\u603b\u7ed3<\/p>\n<p>\u4ed6\u4eec\u4e4b\u95f4\u7684\u4e24\u9879\u6a21\u578b\u7814\u7a76\u8868\u660e\uff0c\u53e3\u670d PrEP 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\u4ec5\u5728\u8fdb\u5165\u90e8\u4f4d\uff08\u5982\u9634\u9053\u73af\u6216\u6740\u83cc\u5242\uff09\u63d0\u4f9b\u9ad8\u6c34\u5e73\u7684\u836f\u7269\uff0c\u672c\u8d28\u4e0a\u53ef\u80fd\u4e0d\u5982\u53e3\u670d\u6216\u6ce8\u5c04\u7684\u5168\u8eab PrEP \u6709\u6548\u3002<\/p>\n<p>\u5c3d\u7ba1\u7814\u7a76\u5f97\u51fa\u7684\u7ed3\u8bba\u662f\uff0c\u53e3\u670d PrEP \u5bf9\u4e8e\u987a\u6027\u522b\u5973\u6027\u6765\u8bf4\u6ca1\u6709\u7406\u7531\u4e0d\u90a3\u4e48\u6709\u6548\uff0c\u4f46\u4ed6\u4eec\u4e0d\u80fd\u8bf4\u4e8b\u4ef6\u9a71\u52a8\u7684\u201c\u6309\u9700\u201dPrEP \u4e0e\u540c\u6027\u604b\u548c\u53cc\u6027\u604b\u7537\u6027\u4e00\u6837\u6709\u6548\uff0c\u56e0\u4e3a\u5b8c\u5168\u7f3a\u4e4f\u5973\u6027\u6570\u636e\u3002<\/p>\n<p>\u8fd9\u4e9b\u7814\u7a76\u4e5f\u6ca1\u6709\u89e3\u91ca\u4e3a\u4ec0\u4e48\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u987a\u6027\u522b\u5973\u6027\u5bf9\u53e3\u670d PrEP 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