{"id":2478,"date":"2024-03-02T14:28:37","date_gmt":"2024-03-02T06:28:37","guid":{"rendered":"http:\/\/baijianyy.cn\/?p=2478"},"modified":"2024-12-12T21:13:41","modified_gmt":"2024-12-12T13:13:41","slug":"%e6%ad%a6%e6%b1%89%e5%b8%82%e6%b1%9f%e6%b1%89%e5%8c%ba%e4%bb%80%e4%b9%88%e6%83%85%e5%86%b5%e4%b8%8b%e9%9c%80%e8%a6%81%e5%90%83%e9%98%bb%e6%96%ad%e8%8d%af%ef%bc%9f%e7%a0%b4%e8%a7%a3hiv%e6%bd%9c","status":"publish","type":"post","link":"http:\/\/baijianyy.cn\/?p=2478","title":{"rendered":"\u6b66\u6c49\u5e02\u6c5f\u6c49\u533a\u4ec0\u4e48\u60c5\u51b5\u4e0b\u9700\u8981\u5403\u963b\u65ad\u836f\uff1f\u7834\u89e3HIV\u6f5c\u5165\u4eba\u7c7b\u7ec6\u80de\u6838\u4e4b\u8c1c\uff0c\u534e\u4eba\u5b66\u8005Nature\u8bba\u6587\u53d1\u73b0\uff0cHIV\u75c5\u6bd2\u8863\u58f3\u8fdb\u5316\u6210\u4e86\u4e00\u79cd\u6838\u8f6c\u8fd0\u86cb\u767d\uff0c\u9003\u8fc7\u7ec6\u80de\u9632\u5fa1\u7cfb\u7edf"},"content":{"rendered":"<p>\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54c1\u9500\u552e\u673a\u6784\uff1f<br \/>\npep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u3001prep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u5168\u56fd\u4e24\u5c0f\u65f6\u6025\u9001\uff0c\u836f\u5e97\u76f4\u53d1\uff0c\u4e13\u4eba\u4e13\u9001<\/p>\n<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85\" target=\"_blank\" rel=\"noopener\">\u827e\u6ecb\u75c5<\/a>HIV\u66b4\u9732\u524d\u540e\u963b\u65ad\u9884\u9632\u7528\u836f\uff0c\u8bf7\u626b\u7801\u6dfb\u52a0\u533b\u9662\u5ba2\u670d\uff0c<strong>\u5168\u56fd\u5404\u57ce\u5e02<\/strong>\u6700\u5feb2\u5c0f\u65f6\u5de6\u53f3\u9001\u8fbe\u3002<\/p>\n<p>\u9ad8\u5371\u884c\u4e3a\u540e\u591a\u4e45\u68c0\u6d4b\uff1f\u9ad8\u5371\u6027\u884c\u4e3a\u4e00\u6b21\u8981\u5403\u963b\u65ad\u836f\u5417\uff1f\u53d1\u751f\u9ad8\u5371\u6027\u884c\u4e3a\u540e\u600e\u4e48\u529e\uff1f\u9ad8\u5371\u884c\u4e3a\u591a\u5c11\u5929\u540e\u53ef\u4ee5\u5f7b\u5e95\u6392\u9664\uff1f\u7b49\u7b49\u95ee\u9898\uff0c\u53ef\u4ee5\u5728\u4e92\u8054\u7f51\u533b\u9662\u514d\u8d39\u54a8\u8be2\u4e13\u4e1a\u611f\u67d3\u79d1\u533b\u5e08\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-127 aligncenter\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/mmexport1702183130138.gif\" alt=\"\" width=\"300\" height=\"300\" \/><\/p>\n<p>\u6b66\u6c49\u5e02\u6c5f\u6c49\u533a\u81ea\u613f\u54a8\u8be2\u68c0\u6d4b\u673a\u6784\uff1a\u6b66\u6c49\u5e02\u6c5f\u6c49\u533a\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3<\/p>\n<p>\u5730\u5740\uff1a \u6b66\u6c49\u5e02\u6c5f\u6c49\u533a\u5e38\u9752\u8857\u9053\u9a6c\u573a\u89d2\u8def50\u53f7<\/p>\n<p>\u4ec0\u4e48\u60c5\u51b5\u4e0b\u9700\u8981\u5403\u963b\u65ad\u836f\uff1f\u6b64\u95ee\u9898\u8bf7\u626b\u4e0a\u9762\u7684\u7801\u5173\u6ce8\u4e92\u8054\u7f51\u533b\u9662\uff0c\u4e3a\u60a8\u89e3\u7b54<\/p>\n<hr \/>\n<p>1981\u5e74\uff0c\u7f8e\u56fd\u75be\u63a7\u4e2d\u5fc3\u9996\u6b21\u62a5\u9053\u4e86\u827e\u6ecb\u75c5\uff08AIDS\uff09\uff0c1983\u5e74\uff0c\u79d1\u5b66\u5bb6\u4eec\u786e\u5b9a\u4e86<a href=\"http:\/\/baijianyy.cn\/?tag=%e4%ba%ba%e5%85%8d%e7%96%ab%e7%bc%ba%e9%99%b7%e7%97%85%e6%af%92\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u4eba\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">\u4eba\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2<\/a>\uff08HIV\uff09\u611f\u67d3\u662f\u5bfc\u81f4\u827e\u6ecb\u75c5\u7684\u539f\u56e0\u300240\u591a\u5e74\u540e\u7684\u4eca\u5929\uff0c\u6211\u4eec\u5df2\u7ecf\u6709\u4e86\u6709\u6548\u6cbb\u7597\u548c\u63a7\u5236<a href=\"http:\/\/baijianyy.cn\/?tag=hiv%e7%97%85%e6%af%92\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201cHIV\u75c5\u6bd2\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">HIV\u75c5\u6bd2<\/a>\u7684\u65b9\u6cd5\uff0c\u4f46\u4ecd\u7136\u65e0\u6cd5\u6cbb\u6108\u827e\u6ecb\u75c5\u3002<\/p>\n<p>HIV\u75c5\u6bd2\u4f1a\u611f\u67d3\u5e76\u52ab\u6301\u514d\u75ab\u7cfb\u7edf\u7684CD4+T\u7ec6\u80de\uff0c\u4ee5\u590d\u5236\u548c\u7e41\u6b96\u81ea\u5df1\u7684\u9057\u4f20\u7269\u8d28\u3002\u827e\u6ecb\u75c5\u60a3\u8005\u7684\u514d\u75ab\u7f3a\u9677\u75c7\u72b6\uff0c\u6b63\u662f\u56e0\u4e3aHIV\u5bf9CD4+T\u7ec6\u80de\u7684\u611f\u67d3\u548c\u653b\u51fb\uff0c\u5bfc\u81f4\u8fd9\u4e9b\u514d\u75ab\u7ec6\u80de\u5927\u91cf\u4e22\u5931\u6240\u81f4\u3002<\/p>\n<p>HIV\u75c5\u6bd2\u4e3a\u4e86\u590d\u5236\u548c\u4f20\u64ad\uff0c\u5fc5\u987b\u5c06\u81ea\u5df1\u7684\u9057\u4f20\u7269\u8d28\u201c\u5077\u8fd0\u201d\u8fdb\u7ec6\u80de\u6838\u5185\u5e76\u6574\u5408\u5230\u67d3\u8272\u4f53\u4e2d\u3002\u7136\u800c\uff0c\u7ec6\u80de\u6838\u88ab\u6838\u819c\u4e25\u5bc6\u4fdd\u62a4\u7740\uff0c\u963b\u6b62\u4e86\u4e0d\u9700\u8981\u7684\u86cb\u767d\u8d28\u6216\u75c5\u6bd2\u8fdb\u5165\uff0c\u5e76\u9632\u6b62\u5927\u5206\u5b50\u4e0d\u53d7\u63a7\u9003\u9038\u3002\u4f46\u6838\u819c\u5e76\u975e\u5b8c\u5168\u5bc6\u5c01\uff0c\u5b83\u4e0a\u9762\u6709\u6210\u5343\u4e0a\u4e07\u4e2a\u5fae\u5c0f\u7684\u6838\u5b54\uff0c\u5b83\u4eec\u501f\u52a9\u6838\u8f6c\u8fd0\u86cb\u767d\uff08\u6838\u8f93\u5165\u86cb\u767d\u3001\u6838\u8f93\u51fa\u86cb\u767d\uff09\u6765\u8c03\u63a7\u7279\u5b9a\u7684\u5206\u5b50\u8fdb\u51fa\u7ec6\u80de\u6838\uff0c\u5355\u4e2a\u6838\u5b54\u6bcf\u79d2\u949f\u53ef\u4ee5\u4f20\u8f93\u9ad8\u8fbe1000\u4e2a\u8f6c\u8fd0\u86cb\u767d\u3002<\/p>\n<p>\u51b7\u51bb\u7535\u955c\u65ad\u5c42\u6210\u50cf\u6280\u672f\u663e\u793a\uff0cHIV\u8863\u58f3\u901a\u8fc7\u6838\u5b54\u8fdb\u5165\u4e86\u7ec6\u80de\u6838\uff0c\u4f46\u8fd9\u91cc\u5b58\u5728\u4e00\u4e2a\u5c3a\u5bf8\u95ee\u9898\u3002\u6838\u5b54\u4e2d\u592e\u5b54\u9053\u7684\u76f4\u5f84\u4e3a40-60\u7eb3\u7c73\uff0c\u5305\u88f9\u75c5\u6bd2\u57fa\u56e0\u7ec4\u7684HIV\u8863\u58f3\u76f4\u5f84\u4e3a60\u7eb3\u7c73\uff0c\u5176\u4e0e\u8f6c\u8fd0\u86cb\u767d\u7ed3\u5408\u540e\u76f4\u5f84\u81f3\u5c11\u518d\u589e\u52a010\u7eb3\u7c73\uff0c\u8fbe\u5230\u4e8670\u7eb3\u7c73\uff0c\u8fd9\u5bf9\u6838\u5b54\u6765\u8bf4\u592a\u5927\u4e86\u3002HIV\u8863\u58f3\u6240\u5982\u4f55\u901a\u8fc7\u6838\u5b54\u8fdb\u5165\u7ec6\u80de\u6838\u7684\u4ecd\u4e0d\u6e05\u695a<\/p>\n<p>2024\u5e741\u670824\u65e5\uff0c\u9a6c\u514b\u65af-\u666e\u6717\u514b\u7814\u7a76\u6240Dirk G\u00f6rlich\u56e2\u961f\u548c\u9ebb\u7701\u7406\u5de5\u5b66\u9662Thomas U. Schwartz\u56e2\u961f\uff08\uff09\u5408\u4f5c\uff0c\u5728 Nature \u671f\u520a\u53d1\u8868\u4e86\u9898\u4e3a\uff1aHIV-1 capsids enter the FG phase of nuclear pores like a transport receptor \u7684\u7814\u7a76\u8bba\u6587\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u53d1\u73b0\uff0c<a href=\"http:\/\/baijianyy.cn\/?tag=hiv%e7%97%85%e6%af%92%e8%a1%a3%e5%a3%b3\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201cHIV\u75c5\u6bd2\u8863\u58f3\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">HIV\u75c5\u6bd2\u8863\u58f3<\/a>\u5df2\u7ecf\u8fdb\u5316\u6210\u4e00\u79cd\u6838\u8f6c\u8fd0\u86cb\u767d\uff0c\u5b83\u53ef\u4ee5\u76f4\u63a5\u7a81\u7834\u4fdd\u62a4\u7ec6\u80de\u6838\u514d\u53d7\u75c5\u6bd2\u5165\u4fb5\u7684\u91cd\u8981\u5c4f\u969c\uff0c\u4e0d\u4f9d\u8d56\u6838\u8f6c\u8fd0\u86cb\u767d\u800c\u7a7f\u8fc7\u6838\u5b54\u8fdb\u5165\u7ec6\u80de\u6838\u3002\u7531\u4e8eHIV\u75c5\u6bd2\u57fa\u56e0\u7ec4\u88ab\u8863\u58f3\u5b8c\u5168\u5c01\u88c5\uff0c\u8fd9\u4e5f\u4f7f\u5f97<a href=\"http:\/\/baijianyy.cn\/?tag=hiv%e5%9f%ba%e5%9b%a0%e7%bb%84\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201cHIV\u57fa\u56e0\u7ec4\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">HIV\u57fa\u56e0\u7ec4<\/a>\u9003\u8fc7\u4eba\u7c7b\u7ec6\u80de\u7684\u7ec6\u80de\u8d28\u4e2d\u7684\u6297\u75c5\u6bd2\u4f20\u611f\u5668\u7684\u8bc6\u522b\uff0c\u7ed5\u8fc7\u7ec6\u80de\u7684\u75c5\u6bd2\u9632\u5fa1\u7cfb\u7edf\uff0c\u5c06\u81ea\u5df1\u7684\u9057\u4f20\u7269\u8d28\u201c\u5077\u8fd0\u201d\u8fdb\u7ec6\u80de\u6838\uff0c\u5e76\u8fdb\u4e00\u6b65\u6574\u5408\u5230\u67d3\u8272\u4f53\u4e2d\u3002<\/p>\n<p>\u6838\u5b54\u590d\u5408\u7269\uff08NPC\uff09\u7531\u7ea630\u79cd\u4e0d\u540c\u7684\u6838\u5b54\u86cb\u767d\uff08Nup\uff09\u6784\u5efa\u800c\u6210\uff0c\u5176\u4e2d\u5305\u62ec\u7ea610\u79cd\u6240\u8c13\u7684FG-Nup\uff0c\u5b83\u4eec\u5c06\u5f62\u6210\u5c4f\u969c\u7684\u82ef\u4e19\u6c28\u9178-\u7518\u6c28\u9178\uff08FG\uff09\u91cd\u590d\u7ed3\u6784\u57df\u951a\u5b9a\u5230NPC\u652f\u67b6\u4e0a\uff0c\u5176\u5448\u51dd\u80f6\u72b6\uff0c\u56e0\u6b64\u4e5f\u88ab\u79f0\u4e3aFG\u76f8\uff08FG 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