{"id":2450,"date":"2024-03-01T15:03:06","date_gmt":"2024-03-01T07:03:06","guid":{"rendered":"http:\/\/baijianyy.cn\/?p=2450"},"modified":"2024-12-12T21:13:52","modified_gmt":"2024-12-12T13:13:52","slug":"%e4%b8%8a%e9%a5%b6%e5%b8%82%e6%a8%aa%e5%b3%b0%e5%8e%bfprep%e8%8d%af%e7%89%a9%e5%9c%a8%e5%93%aa%e9%87%8c%e4%b9%b0mrna%e7%96%ab%e8%8b%97%e6%98%af%e5%90%a6%e5%8f%af%e4%bb%a5%e6%88%90%e4%b8%ba%e7%9c%9f","status":"publish","type":"post","link":"http:\/\/baijianyy.cn\/?p=2450","title":{"rendered":"\u4e0a\u9976\u5e02\u6a2a\u5cf0\u53bfprep\u836f\u7269\u5728\u54ea\u91cc\u4e70?mRNA\u75ab\u82d7\u662f\u5426\u53ef\u4ee5\u6210\u4e3a\u771f\u6b63\u610f\u4e49\u4e0a\u7684\u827e\u6ecb\u75c5\u75ab\u82d7\uff1f"},"content":{"rendered":"<p>\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54c1\u9500\u552e\u673a\u6784\uff1f<br \/>\npep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u3001prep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u5168\u56fd\u4e24\u5c0f\u65f6\u6025\u9001\uff0c\u836f\u5e97\u76f4\u53d1\uff0c\u4e13\u4eba\u4e13\u9001<\/p>\n<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85\" target=\"_blank\" rel=\"noopener\">\u827e\u6ecb\u75c5<\/a>HIV\u66b4\u9732\u524d\u540e\u963b\u65ad\u9884\u9632\u7528\u836f\uff0c\u8bf7\u626b\u7801\u6dfb\u52a0\u533b\u9662\u5ba2\u670d\uff0c<strong>\u5168\u56fd\u5404\u57ce\u5e02<\/strong>\u6700\u5feb2\u5c0f\u65f6\u5de6\u53f3\u9001\u8fbe\u3002<\/p>\n<p>\u9ad8\u5371\u884c\u4e3a\u540e\u591a\u4e45\u68c0\u6d4b\uff1f\u9ad8\u5371\u6027\u884c\u4e3a\u4e00\u6b21\u8981\u5403\u963b\u65ad\u836f\u5417\uff1f\u53d1\u751f\u9ad8\u5371\u6027\u884c\u4e3a\u540e\u600e\u4e48\u529e\uff1f\u9ad8\u5371\u884c\u4e3a\u591a\u5c11\u5929\u540e\u53ef\u4ee5\u5f7b\u5e95\u6392\u9664\uff1f\u7b49\u7b49\u95ee\u9898\uff0c\u53ef\u4ee5\u5728\u4e92\u8054\u7f51\u533b\u9662\u514d\u8d39\u54a8\u8be2\u4e13\u4e1a\u611f\u67d3\u79d1\u533b\u5e08\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-127 aligncenter\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/mmexport1702183130138.gif\" alt=\"\" width=\"300\" height=\"300\" \/><\/p>\n<p>\u4e0a\u9976\u5e02\u6a2a\u5cf0\u53bf\u81ea\u613f\u54a8\u8be2\u68c0\u6d4b\u673a\u6784\uff1a \u94c5\u5c71\u53bf\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3<\/p>\n<p>\u5730\u5740\uff1a\u6a2a\u5cf0\u53bf\u65b0\u5efa\u8def153\u53f7<\/p>\n<p>prep\u836f\u7269\u5728\u54ea\u91cc\u4e70\uff1f\u6b64\u95ee\u9898\u8bf7\u626b\u4e0a\u9762\u7684\u7801\u5173\u6ce8\u4e92\u8054\u7f51\u533b\u9662\uff0c\u4e3a\u60a8\u89e3\u7b54<\/p>\n<hr \/>\n<p>2023\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u6388\u4e88\u4e24\u4f4dmRNA\u75ab\u82d7\u7814\u7a76\u8005\uff0c\u8fd9\u8bc1\u660emRNA\u75ab\u82d7\u7ed9\u672a\u6765\u533b\u5b66\u5e26\u6765\u5de8\u53d8\uff0c\u90a3\u4e48mRNA \u75ab\u82d7\u5bf9HIV\u6709\u6548\u5417\uff1f<\/p>\n<p>\u662f\u7684\uff0cmRNA \u75ab\u82d7\u5f88\u53ef\u80fd\u5bf9 HIV \u6709\u6548\uff0c\u800c\u4e14\u8fd9\u9879\u6280\u672f\u6b63\u5728 HIV \u75ab\u82d7\u7814\u7a76\u4e2d\u8fdb\u884c\u63a2\u7d22\u3002<\/p>\n<p>\u4e0e\u4f20\u7edf\u75ab\u82d7\u76f8\u6bd4\uff0cmRNA \u75ab\u82d7\u5177\u6709\u591a\u79cd\u4f18\u52bf\u3002mRNA \u7684\u5236\u5907\u65e2\u7b80\u5355\u53c8\u5feb\u901f\u3002\u5b83\u4eec\u672c\u8eab\u4e0d\u4f1a\u5728\u4f53\u5185\u505c\u7559\u5f88\u957f\u65f6\u95f4\uff0c\u56e0\u6b64\u4e0d\u592a\u53ef\u80fd\u5f15\u8d77\u526f\u4f5c\u7528\uff1a\u5b83\u4eec\u7684\u4f5c\u7528\u662f\u5f15\u53d1\u514d\u75ab\u53cd\u5e94\uff0c\u7136\u540e\u88ab\u964d\u89e3\u3002\u5b83\u4eec\u4f1a\u4ea7\u751f\u5f3a\u70c8\u7684\u53cd\u5e94\u2014\u2014\u4e8b\u5b9e\u4e0a\uff0c\u5982\u6b64\u5f3a\u70c8\u7684\u53cd\u5e94\u4ee5\u81f3\u4e8e\u65e9\u671f\u7684 mRNA \u75ab\u82d7\u4f7f\u7528\u8d77\u6765\u4e0d\u591f\u5b89\u5168\uff0c\u65e9\u671f\u7684\u5927\u90e8\u5206\u5de5\u4f5c\u90fd\u81f4\u529b\u4e8e\u4f7f\u5b83\u4eec\u4e0d\u6613\u964d\u89e3\u548c\u6bd2\u6027\u8f83\u5c0f\u3002<\/p>\n<p>\u5728\u4eba\u4f53 I \u671f\u5b89\u5168\u6027\u548c\u514d\u75ab\u539f\u6027\u8bd5\u9a8c\u4e2d\uff0c\u56fd\u9645\u827e\u6ecb\u75c5\u75ab\u82d7\u5021\u8bae (IAVI) \u6d4b\u8bd5\u4e86 mRNA \u75ab\u82d7\u3002\u4ed6\u4eec\u5ba3\u5e03\uff0c\u5b83\u5728\u53d7\u8bd5\u8005\u4f53\u5185\u4ea7\u751f\u4e86\u5f3a\u70c8\u7684\u6297 HIV \u6297\u4f53\u53cd\u5e94\uff0c\u523a\u6fc0\u4e86\u80fd\u591f\u4ea7\u751f\u5e7f\u6cdb\u4e2d\u548c\u6297 HIV \u6297\u4f53 VRC01 \u7684 B \u7ec6\u80de\u7684\u53d1\u80b2\u3002<\/p>\n<p>\u4e0e\u6b64\u540c\u65f6\uff0c\u751f\u4ea7\u4e00\u79cd mRNA COVID \u75ab\u82d7\u7684 Moderna \u6700\u521d\u4e00\u76f4\u5728\u5f00\u53d1\u81ea\u5df1\u7684 HIV \u75ab\u82d7\uff0c\u4f46\u4e3a\u4e86\u751f\u4ea7\u65b0\u51a0\u75ab\u82d7\u800c\u6539\u53d8\u4e86\u4ed6\u4eec\u7684\u7814\u7a76\u76ee\u7684\u3002Moderna \u968f\u540e\u51b3\u5b9a\u5c06IAVI \u75ab\u82d7\u63a8\u8fdb\u5230\u5176\u4ed6\u4e00\u671f\u4eba\u4f53\u8bd5\u9a8c\u4e2d\uff0c\u5c06 IAVI \u514d\u75ab\u539f\u4e0e\u4ed6\u4eec\u81ea\u5df1\u7684 mRNA \u9012\u9001\u6280\u672f\u76f8\u7ed3\u5408\u3002<\/p>\n<p>2022\u5e741\u6708\uff0cIAVI\u5ba3\u5e03\u8be5\u75ab\u82d7\u7684IAVI\/Moderna G002\u7814\u7a76\u4e2d\u7684\u7b2c\u4e00\u4f4d\u53d7\u8bd5\u8005\u5df2\u7ecf\u63a5\u53d7\u4e86\u7b2c\u4e00\u9488\u6ce8\u5c04\u3002\u8fd9\u9879 I \u671f\u5b89\u5168\u6027\u548c\u514d\u75ab\u539f\u6027\u7814\u7a76\u6d89\u53ca 56 \u540d\u53c2\u4e0e\u8005\u300232 \u4eba\u5c06\u63a5\u53d7\u542b\u6709\u4e0d\u540c mRNA \u90e8\u5206\u7684\u521d\u514d\u75ab\u82d7\u548c\u52a0\u5f3a\u75ab\u82d7\uff0c16 \u4eba\u5c06\u4ec5\u63a5\u53d7\u521d\u514d\u75ab\u82d7\uff0c8 \u4eba\u5c06\u4ec5\u63a5\u53d7\u52a0\u5f3a\u75ab\u82d7\u3002\u8be5\u8bd5\u9a8c\u5c06\u4e8e 2023 \u5e74 4 \u6708\u7ed3\u675f\u3002\u540e\u7eed\u7597\u6548\u8bd5\u9a8c\u5c06\u53d6\u51b3\u4e8e\u514d\u75ab\u539f\u6027\u7ed3\u679c\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-2451\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2024\/03\/\u5fae\u4fe1\u56fe\u7247_20240301150156.jpg\" alt=\"\" width=\"406\" height=\"230\" \/><\/p>\n<p>\u8fd9\u5e76\u4e0d\u662f\u552f\u4e00\u9700\u8981\u7814\u7a76\u7684 mRNA HIV \u75ab\u82d7\u3002\u5728 2021 \u5e74 CROI \u4f1a\u8bae\u4e0a\uff0c\u7f8e\u56fd\u56fd\u5bb6\u8fc7\u654f\u548c\u4f20\u67d3\u75c5\u7814\u7a76\u6240\u5ba3\u5e03 \uff0c\u540c\u6837\u4e0e Moderna \u5408\u4f5c\u8bbe\u8ba1\u7684 mRNA \u75ab\u82d7\u5728\u7334\u5b50\u8eab\u4e0a\u4ea7\u751f\u4e86\u53ef\u559c\u7684\u7ed3\u679c\uff0c\u5728\u4e00\u5c0f\u7fa4\u4eba\u4e2d\u9884\u9632\u4e86\u9ad8\u8fbe 88% \u7684\u611f\u67d3\u2014\u2014\u5c3d\u7ba1\u6709\u8ff9\u8c61\u8868\u660e\u75ab\u82d7\u7684\u529f\u6548\u53ef\u80fd\u4e0d\u4f1a\u6301\u7eed\u5f88\u957f\u65f6\u95f4\u3002<\/p>\n<p>\u4eba\u4eec\u5bf9 mRNA \u75ab\u82d7\u8868\u793a\u4e86\u4e00\u4e9b\u62c5\u5fe7\uff0c\u56e0\u4e3a\u5b83\u4eec\u542c\u8d77\u6765\u50cf\u662f\u57fa\u56e0\u5de5\u7a0b\uff0c\u793e\u4ea4\u5a92\u4f53\u4e0a\u6709\u6beb\u65e0\u6839\u636e\u7684\u8bf4\u6cd5\u79f0\u5b83\u4eec\u4f1a\u6539\u53d8\u4eba\u4eec\u7684 DNA\u3002\u4f46\u8fd9\u4e9b\u75ab\u82d7\u4e0d\u4f1a\u6539\u53d8\u4eba\u7684\u57fa\u56e0\u3002\u4fe1\u4f7f RNA\uff08m \u4ee3\u8868\u7684\u610f\u601d\uff09\u662f\u666e\u904d\u5b58\u5728\u7684\u77ed\u94fe\u6838\u9178\uff0c\u987e\u540d\u601d\u4e49\uff0c\u662f\u7ec6\u80de\u7684\u4fe1\u4f7f\u3002\u5b83\u4eec\u5bf9\u7ec6\u80de\u6838\u4e2d DNA \u7684\u6307\u4ee4\u8fdb\u884c\u7f16\u7801\uff0c\u5e76\u5c06\u5176\u8fd0\u9001\u5230\u7ec6\u80de\u8d28\u4e2d\uff0c\u6307\u5bfc\u7ec6\u80de\u5236\u9020\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u3002\u4ed6\u4eec\u65e0\u6cd5\u9006\u8f6c\u5e76\u6539\u53d8\u4f60\u7684\u57fa\u56e0\u3002<\/p>\n<p>\u5c31\u65b0\u51a0\u75ab\u82d7\u800c\u8a00\uff0cmRNA \u6307\u793a\u7ec6\u80de\u4ea7\u751f\u5927\u91cf SARS-CoV-2 \u75c5\u6bd2\u7684\u523a\u7a81\u86cb\u767d\u3002\u5b9e\u9645\u4e0a\uff0c\u5b83\u4eec\u4e0d\u662f\u8bd5\u56fe\u5c06\u65b0\u51a0\u75c5\u6bd2\u86cb\u767d\u4f5c\u4e3a\u75ab\u82d7\u5f15\u5165\u4f53\u5185\uff0c\u800c\u662f\u8bf1\u5bfc\u4eba\u4f53\u5236\u9020\u81ea\u5df1\u7684\u75ab\u82d7\u3002<\/p>\n<p>\u5c31 HIV \u800c\u8a00\uff0c\u7531\u4e8e\u9700\u8981\u66f4\u591a\u79cd HIV \u86cb\u767d\u624d\u80fd\u8bf1\u5bfc\u8db3\u591f\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u56e0\u6b64 IAVI\/Moderna \u75ab\u82d7\u5305\u542b\u51e0\u79cd\u4e0d\u540c\u7684 mRNA\uff0c\u53ef\u6307\u5bfc\u7ec6\u80de\u5236\u9020\u4e0d\u540c\u7684 HIV \u6210\u5206\u3002\u7ec6\u80de\u201c\u77e5\u9053\u201d\u5982\u4f55\u5c06\u5b83\u4eec\u7ec4\u88c5\u6210\u75c5\u6bd2\u6837\u9897\u7c92\uff08VLP\uff09\uff0c\u7136\u540e\u5c06\u5176\u53d1\u9001\u5230\u4f53\u5185\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5b83\u4eec\u7f3a\u4e4f\u827e\u6ecb\u75c5\u6bd2\u7684\u590d\u5236\u673a\u5236\uff0c\u56e0\u6b64\u5b83\u4eec\u4e0d\u4f1a\u5f15\u8d77\u611f\u67d3\u3002<\/p>\n<p>VLP \u6b64\u524d\u5df2\u6210\u4e3a\u75ab\u82d7\u7684\u57fa\u7840\u3002\u4eba\u7c7b\u4e73\u5934\u7624\u75c5\u6bd2(HPV) \u75ab\u82d7\u662f\u6709\u53f2\u4ee5\u6765\u6700\u6709\u6548\u7684\u75ab\u82d7\u4e4b\u4e00\uff0c\u53ef\u9884\u9632\u5bab\u9888\u764c\u3001\u809b\u95e8\u764c\u4ee5\u53ca\u4e00\u4e9b\u751f\u6b96\u5668\u75a3\uff0c\u4ee5 VLP \u5f62\u5f0f\u63d0\u4f9b\u3002\u7136\u800c\uff0cmRNA HIV \u75ab\u82d7\u5c06\u6307\u5bfc\u4eba\u4f53\u81ea\u884c\u5236\u9020\u3002<\/p>\n<p>\u4ece\u52a8\u7269\u548c\u7b2c\u4e00\u9636\u6bb5\u7814\u7a76\u5230\u529f\u6548\u7684\u8fc7\u7a0b\u603b\u662f\u6d89\u53ca\u6d88\u9664\u8bb8\u591a\u4e0d\u6210\u529f\u7684\u5019\u9009\u8005\u548c\u65b9\u6cd5\u3002\u8fd9\u53ef\u80fd\u9700\u8981\u51e0\u5e74\u6216\u51e0\u5341\u5e74\u7684\u65f6\u95f4\u3002\u53ea\u6709\u8bd5\u9a8c\u624d\u80fd\u67e5\u660e\u4ee5\u8fd9\u79cd\u5f62\u5f0f\u63d0\u4f9b\u827e\u6ecb\u75c5\u6bd2\u75ab\u82d7\u662f\u5426\u4f1a\u4ea7\u751f\u8db3\u591f\u5f3a\u5927\u548c\u5e7f\u6cdb\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u4ee5\u9884\u9632\u6216\u51cf\u8f7b\u827e\u6ecb\u75c5\u6bd2\u611f\u67d3\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54c1\u9500\u552e\u673a\u6784\uff1f","protected":false},"author":4,"featured_media":2451,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[49,157,61,60,48],"_links":{"self":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/2450"}],"collection":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2450"}],"version-history":[{"count":1,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/2450\/revisions"}],"predecessor-version":[{"id":2452,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/2450\/revisions\/2452"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/media\/2451"}],"wp:attachment":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2450"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}