{"id":1468,"date":"2023-12-29T06:52:45","date_gmt":"2023-12-28T22:52:45","guid":{"rendered":"http:\/\/baijianyy.cn\/?p=1468"},"modified":"2023-12-29T06:52:45","modified_gmt":"2023-12-28T22:52:45","slug":"%e4%b9%90%e5%b1%b1%e5%b8%82%e5%a4%b9%e6%b1%9f%e5%8e%bf-%e9%98%bb%e6%96%ad%e8%8d%af24%e5%b0%8f%e6%97%b6%e5%86%85%e6%88%90%e5%8a%9f%e7%8e%87%ef%bc%9f-%e4%b8%8d%e5%90%8c%e4%ba%9a%e5%9e%8bhiv%e6%84%9f","status":"publish","type":"post","link":"http:\/\/baijianyy.cn\/?p=1468","title":{"rendered":"\u4e50\u5c71\u5e02\u5939\u6c5f\u53bf \u963b\u65ad\u836f24\u5c0f\u65f6\u5185\u6210\u529f\u7387\uff1f \u4e0d\u540c\u4e9a\u578bHIV\u611f\u67d3\u8005\u514d\u75ab\u6062\u590d\u7814\u7a76\u5c06\u52a9\u529b\u7cbe\u7ec6\u5316\u6297\u75c5\u6bd2\u6cbb\u7597"},"content":{"rendered":"<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85\" target=\"_blank\" rel=\"noopener\">\u827e\u6ecb\u75c5<\/a><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54ea\u91cc\u8d2d\u4e70\uff0c<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85\" target=\"_blank\" rel=\"noopener\">\u827e\u6ecb\u75c5<\/a><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u4ef7\u683c\uff0c<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85\" target=\"_blank\" rel=\"noopener\">\u827e\u6ecb\u75c5<\/a><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54c1\u9500\u552e\u673a\u6784\uff1f<br \/>\npep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u3001prep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u5168\u56fd\u4e24\u5c0f\u65f6\u6025\u9001\uff0c\u836f\u5e97\u76f4\u53d1\uff0c\u4e13\u4eba\u4e13\u9001<\/p>\n<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85\" target=\"_blank\" rel=\"noopener\">\u827e\u6ecb\u75c5<\/a>HIV\u66b4\u9732\u524d\u540e\u963b\u65ad\u9884\u9632\u7528\u836f\uff0c\u8bf7\u626b\u7801\u6dfb\u52a0\u533b\u9662\u5ba2\u670d\uff0c<strong>\u5168\u56fd\u5404\u57ce\u5e02<\/strong>\u6700\u5feb2\u5c0f\u65f6\u5de6\u53f3\u9001\u8fbe\u3002<\/p>\n<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u9ad8\u5371\u884c\u4e3a\u540e\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%ab%98%e5%8d%b1%e8%a1%8c%e4%b8%ba%e5%90%8e\" target=\"_blank\" rel=\"noopener\">\u9ad8\u5371\u884c\u4e3a\u540e<\/a>\u591a\u4e45\u68c0\u6d4b\uff1f<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u9ad8\u5371\u6027\u884c\u4e3a\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%ab%98%e5%8d%b1%e6%80%a7%e8%a1%8c%e4%b8%ba\" target=\"_blank\" rel=\"noopener\">\u9ad8\u5371\u6027\u884c\u4e3a<\/a>\u4e00\u6b21\u8981\u5403<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u5417\uff1f\u53d1\u751f\u9ad8\u5371\u6027\u884c\u4e3a\u540e\u600e\u4e48\u529e\uff1f\u9ad8\u5371\u884c\u4e3a\u591a\u5c11\u5929\u540e\u53ef\u4ee5\u5f7b\u5e95\u6392\u9664\uff1f\u7b49\u7b49\u95ee\u9898\uff0c\u53ef\u4ee5\u5728\u4e92\u8054\u7f51\u533b\u9662\u514d\u8d39\u54a8\u8be2\u4e13\u4e1a\u611f\u67d3\u79d1\u533b\u5e08\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-362 aligncenter\" title=\"mmexport1702183130138-5.gif\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/mmexport1702183130138-5.gif\" alt=\"\u4e50\u5c71\u5e02 \u5ce8\u7709\u5c71\u5e02 \u827e\u6ecb\u75c5\u963b\u65ad\u836f\u8981\u591a\u5c11\u94b1\uff1f\u827e\u6ecb\u75c5\u6cbb\u7597\u7684\u65b0\u5e0c\u671b\u2014\u2014\u5e7f\u8c31\u4e2d\u548c\u6297\u4f53\" width=\"300\" height=\"300\" \/><\/p>\n<p>\u4e50\u5c71\u5e02\u5939\u6c5f\u53bf\u81ea\u613f\u54a8\u8be2\u68c0\u6d4b\u673a\u6784\uff1a\u5939\u6c5f\u53bf\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3<\/p>\n<p>\u5730\u5740\uff1a \u5939\u6c5f\u53bf\u7109\u57ce\u9547\u897f\u6cb3\u8def30\u53f7<\/p>\n<p><strong>\u963b\u65ad\u836f24\u5c0f\u65f6\u5185\u6210\u529f\u7387\uff1f \u6b64\u95ee\u9898\u8bf7\u626b\u4e0a\u9762\u7684\u7801\u5173\u6ce8\u4e92\u8054\u7f51\u533b\u9662\uff0c\u4e3a\u60a8\u89e3\u7b54\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-1470 aligncenter\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/\u5fae\u4fe1\u622a\u56fe_20231229065154.jpg\" alt=\"\" width=\"432\" height=\"447\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u636e2018\u5e74\u6211\u56fd\u5206\u5b50\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u7ed3\u679c\u663e\u793a\uff0cHIV-1 CRF01_AE\u548cCRF07_BC\u5206\u522b\u5360\u5f53\u5e74\u62a5\u544a\u611f\u67d3\u8005\u4eba\u7fa4\u768436.2\uff05\u548c40.8\uff05\uff0c\u5176\u5df2\u6210\u4e3a\u6211\u56fd\u827e\u6ecb\u75c5\u4e3b\u8981\u6d41\u884c\u6bd2\u682a\u3002\u73b0\u4eca\uff0c\u6709\u5173\u827e\u6ecb\u75c5\u6cbb\u7597\u540e\u514d\u75ab\u6062\u590d\u7684\u7814\u7a76\u5927\u591a\u6570\u9488\u5bf9\u662f\u6b27\u7f8e\u5730\u533a\u7684HIV-1 B\u4e9a\u578b\u60a3\u8005\uff0c\u800c\u5bf9\u4e8e\u611f\u67d3CRF01_AE\u548cCRF07_BC\u4e9a\u578b\u4eba\u7fa4\u7814\u7a76\u8f83\u5c11\uff0c\u56e0\u6b64\u6709\u5fc5\u8981\u6df1\u5165\u63a2\u7a76\u4e0d\u540c\u4e9a\u578b\u60a3\u8005\u7684\u514d\u75ab\u6062\u590d\u8fdb\u5c55\u60c5\u51b5\u53ca\u5176\u4e0e\u5bbf\u4e3b\u514d\u75ab\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u5dee\u5f02\uff0c\u8fd9\u5bf9\u4e8e\u5236\u8ba2\u66f4\u52a0\u7cbe\u7ec6\u5316\u7684HIV\u6cbb\u7597\u65b9\u6848\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<p>2019\u5e74\u4e2d\u56fd\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3\u6027\u75c5\u827e\u6ecb\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3\u90b5\u4e00\u9e23\u56e2\u961f\u5728\u300a\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u62a5\u300b\uff08PNAS\uff09\u53d1\u8868\u4e86\u91cd\u8981\u6587\u7ae0\uff0c\u5176\u9996\u6b21\u8bc1\u660e\u4e86\u540c\u4e00HIV\u4e9a\u578b\u4e2d\u7684\u4e0d\u540c\u6bd2\u682a\u7c07\u4e5f\u5177\u6709\u7740\u4e0d\u540c\u7684\u514d\u75ab\u635f\u4f24\u8868\u578b\u3002\u5e76\u4e14\u7814\u7a76\u4ee5\u8be6\u5b9e\u6570\u636e\u63a2\u7a76\u4e86HIV-1 CRF01AE\u6bd2\u682a\u7531R5\u5411X4\u8f6c\u6362\u7684\u9608\u503c\uff0c\u4ee5\u53ca\u5728\u5206\u5b50\u6c34\u5e73\u63ed\u793a\u4e86\u5185\u90e8C4\u3001C5\u7c07\u75c5\u6bd2\u4e0e\u9776\u7ec6\u80deX4\u548cR5\u8f85\u52a9\u53d7\u4f53\u7ed3\u5408\u7684\u7ed3\u6784\u57fa\u7840\u3002\u8be5\u7814\u7a76\u8868\u660e\u4e0d\u540c\u7cfb\u7edf\u53d1\u80b2\u7c07\u4e4b\u95f4HIV-1\u7684\u8868\u578b\u4e0d\u540c\uff0c\u5e76\u5f3a\u8c03\u5728\u57fa\u56e0\u578b\u548c\u8868\u578b\u6c34\u5e73\u4e0a\u5bf9HIV-1\u8fdb\u5316\u76d1\u6d4b\uff0c\u8fd9\u5bf9\u4e8e\u9274\u5b9a\u548c\u63a7\u5236\u66f4\u591a\u7684\u81f4\u75c5\u6027HIV-1\u83cc\u682a\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-1469\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/\u5fae\u4fe1\u56fe\u7247_20231229064952.png\" alt=\"\" width=\"607\" height=\"647\" \/><\/p>\n<p>\u6211\u56fd\u4e3b\u8981HIV\u4e9a\u578b\u548c\u4e9a\u7c07\u5728cART\u671f\u95f4\u8fbe\u5230\u514d\u75ab\u6062\u590d\u548c\u65e9\u671f\u514d\u75ab\u6062\u590d\u6bd4\u4f8b\u7684\u6bd4\u8f83<\/p>\n<p>\u5728\u4e0a\u8ff0\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0c\u90b5\u4e00\u9e23\u6559\u6388\u7814\u7a76\u56e2\u961f\u63a5\u7740\u9488\u5bf9\u4e0d\u540cHIV\u4e9a\u578b\/\u4e9a\u7c07\u60a3\u8005\u8fdb\u884c\u4e86\u968f\u8bbf\u8c03\u67e5\uff0c\u4ee5\u89c2\u5bdf\u611f\u67d3\u8005\u5728\u8054\u5408\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u6cbb\u7597\uff08cART\uff09\u671f\u95f4\u7684\u514d\u75ab\u6062\u590d\u60c5\u51b5\uff0c\u5e76\u5bf9\u76f8\u5173\u7684\u5f71\u54cd\u56e0\u7d20\u8fdb\u884c\u4e86\u6df1\u5165\u5206\u6790\uff0c\u4ecb\u7ecd\u8be5\u5de5\u4f5c\u7684\u8bba\u6587\u5df2\u53d1\u8868\u4e8e\u56fd\u9645\u5b66\u672f\u671f\u520a\u300a\u4e34\u5e8a\u4f20\u67d3\u75c5\u6742\u5fd7\u300b\uff08Clinical Infectious Diseases\uff09\u3002\u5176\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5728\u63a5\u53d7cART\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u9664\u57fa\u7ebfCD4+T\u6dcb\u5df4\u7ec6\u80de\u6c34\u5e73\u548c\u5e74\u9f84\u7b49\u56e0\u7d20\u4e0e\u514d\u75ab\u6062\u590d\u80fd\u529b\u76f8\u5173\u5916\uff0cCRF01_AE\u4e9a\u578b\u60a3\u8005\u4e0eCRF07_BC\u4e9a\u578b\u60a3\u8005\u76f8\u6bd4\u5176\u514d\u75ab\u6062\u590d\u6c34\u5e73\u66f4\u5dee\u3002\u800c\u5728CRF01_AE\u4e9a\u578b\u5185\u90e8\u4e9a\u7c07\u4e2d\uff0c C4\u7c07\u60a3\u8005\u76f8\u5bf9\u4e8e C5\u7c07\u60a3\u8005\u5176\u514d\u75ab\u6062\u590d\u66f4\u5dee\u3002\u5728\u8fdb\u4e00\u6b65\u7684\u673a\u5236\u7814\u7a76\u53d1\u73b0\uff0cCRF01_AE\u548cCRF01_AE C4\u7c07\u60a3\u8005\u514d\u75ab\u6062\u590d\u66f4\u5dee\u7684\u539f\u56e0\u662f\u7531\u4e8e\u4e24\u8005\u62e5\u6709\u7740\u66f4\u9ad8\u6bd4\u4f8b\u7684X4\u55dc\u6027\u75c5\u6bd2\u3002\u56e0\u6b64\u4e3a\u4e86\u63d0\u9ad8\u6211\u56fdHIV\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\uff0c\u4ed6\u4eec\u5efa\u8bae\u5bf9\u4e8e\u5404\u5730\u533a\u827e\u6ecb\u75c5\u60a3\u8005cART\u6cbb\u7597\u65b9\u6848\u7684\u5236\u5b9a\u5e94\u5145\u5206\u8003\u8651\u5f53\u5730HIV\u7684\u4e9a\u578b\u548c\u4e9a\u7c07\u7c7b\u578b\uff0c\u540c\u65f6\u8fd8\u6307\u51fa\u5728\u6211\u56fdX4\u55dc\u6027HIV\u75c5\u6bd2\u9ad8\u6d41\u884c\u533a\u5e94\u8c28\u614e\u4f7f\u7528CCR5\u6291\u5236\u5242\u3002\u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u9996\u6b21\u5bf9\u4e2d\u56fd\u6d41\u884c\u7684\u4e3b\u8981\u4e9a\u578b\u548c\u4e9a\u7c07cART\u6cbb\u7597\u671f\u95f4\u514d\u75ab\u6062\u590d\u60c5\u51b5\u8fdb\u884c\u4e86\u6df1\u5165\u5206\u6790\uff0c\u8fd8\u4e3a\u6211\u56fd\u5c06\u6765\u66f4\u52a0\u7cbe\u7ec6\u5316HIV\u60a3\u8005cART\u65b9\u6848\u7684\u5236\u8ba2\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54c1\u9500\u552e\u673a\u6784\uff1f","protected":false},"author":5,"featured_media":1470,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5,3,4,57],"tags":[77,61,60],"_links":{"self":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/1468"}],"collection":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1468"}],"version-history":[{"count":1,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/1468\/revisions"}],"predecessor-version":[{"id":1471,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/1468\/revisions\/1471"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/media\/1470"}],"wp:attachment":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1468"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}