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\u827e\u6ecb\u75c5<\/a>\u963b\u65ad\u836f<\/a>\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5<\/a>\u963b\u65ad\u836f<\/a>\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5<\/a>\u963b\u65ad\u836f<\/a>\u54c1\u9500\u552e\u673a\u6784\uff1f
\npep\u963b\u65ad\u836f<\/a>\u3001prep\u963b\u65ad\u836f<\/a>\u5168\u56fd\u4e24\u5c0f\u65f6\u6025\u9001\uff0c\u836f\u5e97\u76f4\u53d1\uff0c\u4e13\u4eba\u4e13\u9001<\/p>\n

\u827e\u6ecb\u75c5<\/a>HIV\u66b4\u9732\u524d\u540e\u963b\u65ad\u9884\u9632\u7528\u836f\uff0c\u8bf7\u626b\u7801\u6dfb\u52a0\u533b\u9662\u5ba2\u670d\uff0c\u5168\u56fd\u5404\u57ce\u5e02<\/strong>\u6700\u5feb2\u5c0f\u65f6\u5de6\u53f3\u9001\u8fbe\u3002<\/p>\n

\u9ad8\u5371\u884c\u4e3a\u540e<\/a>\u591a\u4e45\u68c0\u6d4b\uff1f\u9ad8\u5371\u6027\u884c\u4e3a<\/a>\u4e00\u6b21\u8981\u5403\u963b\u65ad\u836f<\/a>\u5417\uff1f\u53d1\u751f\u9ad8\u5371\u6027\u884c\u4e3a\u540e\u600e\u4e48\u529e\uff1f\u9ad8\u5371\u884c\u4e3a\u591a\u5c11\u5929\u540e\u53ef\u4ee5\u5f7b\u5e95\u6392\u9664\uff1f\u7b49\u7b49\u95ee\u9898\uff0c\u53ef\u4ee5\u5728\u4e92\u8054\u7f51\u533b\u9662\u514d\u8d39\u54a8\u8be2\u4e13\u4e1a\u611f\u67d3\u79d1\u533b\u5e08\u3002<\/p>\n

\"\u4e50\u5c71\u5e02<\/p>\n

\u4e50\u5c71\u5e02\u4e95\u7814\u53bf\u81ea\u613f\u54a8\u8be2\u68c0\u6d4b\u673a\u6784\uff1a\u4e95\u7814\u53bf\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3<\/p>\n

\u5730\u5740\uff1a \u4e50\u5c71\u5e02\u4e95\u7814\u53bf\u7814\u57ce\u8857\u9053\u6c34\u4ead\u5df735\u53f7<\/p>\n

\u827e\u6ecb\u7a97\u53e3\u671f\u6700\u957f\u591a\u5c11\u5929\uff1f \u6b64\u95ee\u9898\u8bf7\u626b\u4e0a\u9762\u7684\u7801\u5173\u6ce8\u4e92\u8054\u7f51\u533b\u9662\uff0c\u4e3a\u60a8\u89e3\u7b54\u3002<\/strong><\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

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\"\"
\n\u56fe1 HIV\u75c5\u6bd2\u7ed3\u6784<\/p>\n

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\"\"<\/p>\n

\u56fe2 \u5c06HIV\u75c5\u6bd2\u7684\u57fa\u56e0\u7247\u6bb5\u5d4c\u5165\u817a\u75c5\u6bd2<\/p>\n

\u9996\u5148\uff0c\u7531\u4e8e\u201cMosaic\u201d\u75ab\u82d7\u4e2d\u5305\u542b\u4e86\u591a\u79cdHIV\u7684\u57fa\u56e0\u7247\u6bb5\uff0c\u80fd\u591f\u8986\u76d6\u5168\u7403\u5927\u591a\u6570\u7684HIV\u6bd2\u682a\uff0c\u5176\u6700\u5927\u7684\u4f18\u52bf\u5c31\u662f\u80fd\u8bf1\u5bfc\u673a\u4f53\u4ea7\u751f\u9488\u5bf9\u591a\u79cdHIV\u6bd2\u682a\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u589e\u5f3a\u4e86\u673a\u4f53\u8bc6\u522b\u4e0d\u540cHIV\u6bd2\u682a\u7684\u80fd\u529b1\uff0c\u6709\u5229\u4e8e\u5e94\u5bf9HIV\u7684\u9ad8\u5ea6\u53d8\u5f02\u3002<\/p>\n

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2017\u5e74\uff0cDan H. Barouch\u7b49\u79d1\u5b66\u5bb6\u7814\u53d1\u7684\u201cMosaic\u201d\u827e\u6ecb\u75c5\u75ab\u82d7\u5f00\u59cb\u4e86I\/IIa\u4e34\u5e8a\u8bd5\u9a8c\uff1a\u7528\u542b\u6709HIV\u201cMosaic\u201d\u57fa\u56e0\u7684\u817a\u75c5\u6bd2\u4f5c\u4e3a\u514d\u75ab\u539f\uff0c\u968f\u540e\u7528gp140\u5305\u819c\u86cb\u767d\u589e\u5f3a\u514d\u75ab\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u75ab\u82d7\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u5728\u6052\u6cb3\u7334\u548c\u4eba\u4f53\u5747\u8bf1\u5bfc\u4e86\u5f3a\u5927\u7684\u4f53\u6db2\u548c\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u3002\u76ee\u524d\u75ab\u82d7\u6b63\u5728\u8fdb\u884c\u2161B\u4e34\u5e8a\u8bd5\u9a8c1\u3002<\/p>\n

\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\uff0cKathryn E Stephenson\u7b49\u4eba\u91c7\u7528\u4e86\u514d\u75ab\u65f6\u95f4\u66f4\u77ed\u3001\u65b9\u6cd5\u66f4\u7b80\u5355\u7684\u75ab\u82d7\u63a5\u79cd\u65b9\u6848\uff0c\u6765\u8bc4\u4f30\u75ab\u82d7\u7684\u5b89\u5168\u6027\u3001\u514d\u75ab\u539f\u6027\u548c\u8010\u53d7\u6027\u662f\u5426\u53d1\u751f\u6539\u53d8\u3002\u76f8\u8f83\u4e8eDan\u768412\u4e2a\u6708\u63a5\u79cd\u65b9\u6848\uff0c 6\u4e2a\u6708\u7684\u63a5\u79cd\u65b9\u6848\u8bf1\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\u7684\u5f3a\u5ea6\u672a\u89c1\u964d\u4f4e3\u3002\u8fd9\u4e3a\u75ab\u82d7\u7814\u5236\u6210\u529f\u540e\u7684\u5feb\u901f\u666e\u53ca\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002\u76ee\u524d\uff0c\u56db\u4ef7\u201cMosaic\u201d\u75ab\u82d7\u4e5f\u5b8c\u6210\u4e86I\/IIa\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4e0e\u4e09\u4ef7\u75ab\u82d7\u76f8\u6bd4\uff0c\u56db\u4ef7\u75ab\u82d7\u8bf1\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\u5f3a\u5ea6\u548c\u5e7f\u5ea6\u66f4\u5177\u4f18\u52bf4\u3002<\/p>\n

\"\"
\n\u56fe3 CTLs\u8bc6\u522bHIV\u75c5\u6bd2\u5e76\u6291\u5236\u5176\u590d\u5236<\/p>\n

\u4e0e\u5176\u4ed6\u7c7b\u578b\u75ab\u82d7\u7684\u4e0d\u540c\uff0c\u201cMosaic\u201d\u75ab\u82d7\u878d\u5408\u4e86\u6765\u81ea\u4e16\u754c\u5404\u5730\u7684HIV\u6bd2\u682a\u7684\u9057\u4f20\u7269\u8d28\uff0c\u53ef\u4ee5\u8bf1\u5bfc\u66f4\u4e3a\u5e7f\u8c31\u7684\u514d\u75ab\u53cd\u5e945\u3002\u8fd9\u4e00\u8bbe\u8ba1\u7b56\u7565\u6709\u53ef\u80fd\u6d88\u9664HIV\u75c5\u6bd2\u9ad8\u5ea6\u53d8\u5f02\u5bf9\u75ab\u82d7\u7814\u53d1\u6240\u9020\u6210\u7684\u963b\u788d\uff0c\u4e3a\u827e\u6ecb\u75c5\u75ab\u82d7\u7684\u7814\u53d1\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n

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