{"id":1104,"date":"2023-12-21T23:28:32","date_gmt":"2023-12-21T15:28:32","guid":{"rendered":"http:\/\/baijianyy.cn\/?p=1104"},"modified":"2023-12-21T23:28:32","modified_gmt":"2023-12-21T15:28:32","slug":"%e9%87%8d%e5%ba%86%e5%b7%ab%e5%b1%b1%e5%8e%bf%e9%98%bb%e6%96%ad%e8%8d%af%e6%80%8e%e4%b9%88%e9%98%bb%e6%96%ad%ef%bc%9fhiv%e9%98%bb%e6%96%ad%e5%89%82%e7%9a%84%e4%bd%9c%e7%94%a8%e6%9c%ba%e5%88%b6","status":"publish","type":"post","link":"http:\/\/baijianyy.cn\/?p=1104","title":{"rendered":"\u91cd\u5e86\u5deb\u5c71\u53bf\u963b\u65ad\u836f\u600e\u4e48\u963b\u65ad\uff1fHIV\u963b\u65ad\u5242\u7684\u4f5c\u7528\u673a\u5236\u539f\u7406"},"content":{"rendered":"<p>\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u54c1\u9500\u552e\u673a\u6784\uff1f<br \/>\npep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u3001prep<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u836f\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e8%8d%af\" target=\"_blank\" rel=\"noopener\">\u963b\u65ad\u836f<\/a>\u5168\u56fd\u4e24\u5c0f\u65f6\u6025\u9001\uff0c\u836f\u5e97\u76f4\u53d1\uff0c\u4e13\u4eba\u4e13\u9001<\/p>\n<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u827e\u6ecb\u75c5\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e8%89%be%e6%bb%8b%e7%97%85\" target=\"_blank\" rel=\"noopener\">\u827e\u6ecb\u75c5<\/a>HIV\u66b4\u9732\u524d\u540e\u963b\u65ad\u9884\u9632\u7528\u836f\uff0c\u8bf7\u626b\u7801\u6dfb\u52a0\u533b\u9662\u5ba2\u670d\uff0c<strong>\u5168\u56fd\u5404\u57ce\u5e02<\/strong>\u6700\u5feb2\u5c0f\u65f6\u5de6\u53f3\u9001\u8fbe\u3002<\/p>\n<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u9ad8\u5371\u884c\u4e3a\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%ab%98%e5%8d%b1%e8%a1%8c%e4%b8%ba\" target=\"_blank\" rel=\"noopener\">\u9ad8\u5371\u884c\u4e3a<\/a>\u540e\u591a\u4e45\u68c0\u6d4b\uff1f<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u9ad8\u5371\u6027\u884c\u4e3a\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%ab%98%e5%8d%b1%e6%80%a7%e8%a1%8c%e4%b8%ba\" target=\"_blank\" rel=\"noopener\">\u9ad8\u5371\u6027\u884c\u4e3a<\/a>\u4e00\u6b21\u8981\u5403\u963b\u65ad\u836f\u5417\uff1f\u53d1\u751f<a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u9ad8\u5371\u6027\u884c\u4e3a\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%ab%98%e5%8d%b1%e6%80%a7%e8%a1%8c%e4%b8%ba\" target=\"_blank\" rel=\"noopener\">\u9ad8\u5371\u6027\u884c\u4e3a<\/a>\u540e\u600e\u4e48\u529e\uff1f\u9ad8\u5371\u884c\u4e3a\u591a\u5c11\u5929\u540e\u53ef\u4ee5\u5f7b\u5e95\u6392\u9664\uff1f\u7b49\u7b49\u95ee\u9898\uff0c\u53ef\u4ee5\u5728\u4e92\u8054\u7f51\u533b\u9662\u514d\u8d39\u54a8\u8be2\u4e13\u4e1a\u611f\u67d3\u79d1\u533b\u5e08\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-127 aligncenter\" title=\"mmexport1702183130138.gif\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/mmexport1702183130138.gif\" alt=\"\u91cd\u5e86\u6b66\u9686\u533a\u827e\u6ecb\u6709\u963b\u65ad\u836f\u5417\uff1f\u827e\u6ecb\u75c5\u75c5\u6f5c\u4f0f\u671f\u6216\u65e0\u75c7\u72b6\u671f\u6709\u591a\u957f\uff1f\" width=\"300\" height=\"300\" \/><\/p>\n<p><a class=\"tag_link\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u91cd\u5e86\u201d\u7684\u6587\u7ae0\" href=\"http:\/\/baijianyy.cn\/?tag=%e9%87%8d%e5%ba%86\" target=\"_blank\" rel=\"noopener\">\u91cd\u5e86<\/a>\u5e02<a href=\"http:\/\/baijianyy.cn\/?tag=%e5%b7%ab%e5%b1%b1%e5%8e%bf\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u5deb\u5c71\u53bf\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">\u5deb\u5c71\u53bf<\/a>\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3<\/p>\n<p>\u5730\u5740\uff1a \u5deb\u5c71\u53bf\u5e7f\u4e1c\u4e2d\u8def123\u53f7<\/p>\n<p>\u963b\u65ad\u836f\u600e\u4e48\u963b\u65ad\uff1f<\/p>\n<p>\u9ad8\u6548\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u6cbb\u7597\u6cd5\uff08HAART\uff09\u662f\u76ee\u524d\u6cbb\u7597HIV\u60a3\u8005\u6700\u6709\u6548\u3001\u6700\u5e38\u7528\u7684\u65b9\u6cd5\uff0c\u80fd\u591f\u4ee5\u6700\u5927\u9650\u5ea6\u6291\u5236HIV\u75c5\u6bd2\u7684\u590d\u5236\uff0c\u5c55\u73b0\u51fa\u5f3a\u5927\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\u3002\u5176\u5728HIV\u75c5\u6bd2\u611f\u67d3\u5bbf\u4e3b\u7ec6\u80de\u65f6\u5728\u4e0d\u540c\u9636\u6bb5\u7684\u4e0d\u540c\u4f5c\u7528\u673a\u5236\u5982\u4e0b\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-1105\" src=\"http:\/\/baijianyy.cn\/wp-content\/uploads\/2023\/12\/HIV\u963b\u65ad\u5242\u7684\u4f5c\u7528\u673a\u5236.png\" alt=\"\" width=\"704\" height=\"389\" \/><\/p>\n<p>\u4e00\u3001\u878d\u5408\u6291\u5236\u3001\u963b\u65adHIV\u5efa\u7acb\u611f\u67d3\u4f53\u7cfb<br \/>\n\u8fd9\u7c7b\u6291\u5236\u5242\u4f5c\u7528\u4e8e\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u524d\u7684\u9636\u6bb5\uff0c\u4ee5\u5e72\u6270HIV\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u7684\u7c98\u9644\u3001\u878d\u5408\u800c\u8fbe\u5230\u6297\u75c5\u6bd2\u7684\u4f5c\u7528\u3002\u5177\u4f53\u836f\u7269\u5206\u4e3a\u4e24\u5927\u7c7b\uff0c\u4e00\u79cd\u836f\u7269\u662fCCR5\u6291\u5236\u5242\uff0c\u4e3b\u8981\u9488\u5bf9\u4e8e\u7ec6\u80de\u819c\u8d8b\u5316\u56e0\u5b50\u8f85\u52a9\u53d7\u4f53\uff0c\u53e6\u4e00\u79cd\u836f\u7269\u662f\u878d\u5408\u9176\u6291\u5236\u5242\uff0c\u9488\u5bf9\u75c5\u6bd2\u819c\u86cb\u767dgp120\u3001gp41\u4f5c\u7528\u3002<\/p>\n<p>\uff081\uff09\u8d8b\u5316\u56e0\u5b50\u8f85\u52a9\u53d7\u4f53<br \/>\n\u7531\u4e8e\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u662fHIV-1\u5165\u4fb5\u7684\u8f85\u52a9\u53d7\u4f53\uff0c\u5373\u53ef\u901a\u8fc7\u653b\u51fb\u8f85\u52a9\u53d7\u4f53\u8fdb\u800c\u963b\u65adHIV\u75c5\u6bd2\u7684\u611f\u67d3\u3002\u5e38\u89c1\u7684\u8f85\u52a9\u53d7\u4f53\u6709CCR5\u3001CXCR4\uff0c\u5f53\u653b\u51fb\u8fd9\u4e24\u79cd\u53d7\u4f53\u65f6\uff0c\u5373\u53ef\u963b\u65adHIV-1\u75c5\u6bd2\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u3002\u8fd1\u5e74\u6765\uff0c\u5927\u91cf\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\u88ab\u53d1\u73b0\uff1a\u5982\u57fa\u8d28\u7ec6\u80de\u884d\u751f\u56e0\u5b50\u20141\u548c\u8c03\u8282\u6d3b\u6027\u6b63\u5e38T\u7ec6\u80de\u7684\u8868\u8fbe\u5206\u6ccc\u86cb\u767d\uff0c\u90fd\u662fCCR5\u548cCXCR4\u7684\u5929\u7136\u6297\u4f53\uff0c\u80fd\u5206\u522b\u6291\u5236\u75c5\u6bd2\u590d\u5236\u548c\u5165\u4fb5\u3002\u5982UK-427,857(Maraviroc)\u5c31\u662f\u4e00\u4e2a\u901a\u8fc7\u9ad8\u901a\u91cf\u7684\u7b5b\u9009\u548c\u836f\u7269\u5408\u6210\u7684\u9009\u62e9\u6027CCR5\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u6709\u5f88\u5f3a\u7684\u6297HIV-1\u6d3b\u6027\u7684\u4f5c\u7528\uff0c\u5b83\u963b\u6b62\u4e86\u75c5\u6bd2\u8868\u9762\u5305\u819c\u86cb\u767d\u548cCCR5\u4e4b\u95f4\u7684\u9ecf\u9644\uff0c\u4ece\u800c\u963b\u6b62\u4e86\u75c5\u6bd2\u4fb5\u5165\u878d\u5408\u4e8e\u9776\u7ec6\u80de\uff1b\u81ea\u7136\u754c\u4e2d\u5206\u5e03\u5728\u5357\u975e\u7684\u843d\u53f6\u6811\u7684\u5e72\u6811\u76ae\u63d0\u53d6\u7269\u767d\u6866\u9178\u5bf9HIV\u3001\u6027\u75c5\u548c\u4e0d\u5b55\u4e5f\u6709\u6cbb\u7597\u6548\u679c\uff0c\u6b63\u662f\u56e0\u4e3a\u767d\u6866\u9178\u80fd\u591f\u6291\u5236HIV-1\u7684\u6d3b\u6027\uff0c\u4e5f\u5bf9CXCR4\u548cCCR5\u6709\u6291\u5236\u4f5c\u7528\uff0c\u6291\u5236\u8f85\u52a9\u53d7\u4f53\u3002<\/p>\n<p>\uff082\uff09\u819c\u86cb\u767dgp120\u3001gp41\u4f5c\u7528<br \/>\n\u5f53HIV\u75c5\u6bd2\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u65f6\uff0c\u819c\u86cb\u767dgp120\u4fbf\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u8868\u9762\u4e0a\u7684CD4\u53d7\u4f53\u7ed3\u5408\uff0c\u4f7fgp120\u7684\u7ed3\u6784\u53d1\u751f\u53d8\u5316\uff0c\u6b64\u65f6\u8de8\u819c\u86cb\u767dgp41\u88ab\u66b4\u9732\uff0c\u5bfc\u81f4gp41\u548cgp120\u86cb\u767d\u5206\u88c2\u3002\u5b58\u5728\u4e8egp41\u7684\u4e03\u80bd\u91cd\u590d\u533a\u88ab\u66b4\u9732\u51fa\u6765\u5e76\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u819c\u4f5c\u7528\uff0c\u7ee7\u800c\u5f62\u6210\u4e86\u819c\u86cb\u767dgp41\u7684\u6838\u5fc3\u4e09\u805a\u4f53\u53d1\u5939\u72b6\u7ed3\u6784\uff0c\u6700\u7ec8\u5f62\u6210\u75c5\u6bd2\u53d1\u5939\u3002\u7814\u7a76\u8868\u660e\uff0c\u75c5\u6bd2\u53d1\u5939\u7ed3\u6784N\u7aef\u9690\u85cf\u533a\u5f71\u54cd\u7740\u516d\u805a\u4f53\u7684\u7a33\u5b9a\u6027\uff0c\u7531\u6b64\u9020\u6210\u7684\u7ed3\u6784\u4e0a\u7684\u6539\u53d8\u4f7fHIV-1\u6700\u7ec8\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u963b\u6b62gp41\u6838\u5fc3\u4e09\u805a\u4f53\u53d1\u5939\u88c5\u7684\u7ed3\u6784\u5f62\u6210\uff0c\u4e5f\u5c31\u80fd\u591f\u963b\u6b62HIV\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\uff0c\u4ece\u800c\u6291\u5236HIV-1\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u878d\u5408\uff0c\u751f\u6d3b\u4e2d\u5e38\u89c1\u7684\u6838\u6843\u58f3\u4f5c\u4e3aHIV<a href=\"http:\/\/baijianyy.cn\/?tag=%e9%98%bb%e6%96%ad%e5%89%82\" title=\"\u6d4f\u89c8\u5173\u4e8e\u201c\u963b\u65ad\u5242\u201d\u7684\u6587\u7ae0\" target=\"_blank\" class=\"tag_link\">\u963b\u65ad\u5242<\/a>\uff0c\u6b63\u662f\u5229\u7528\u4e86\u8fd9\u79cd\u673a\u5236\u3002\u7ecf\u7814\u7a76\u8868\u660e\u6838\u6843\u58f3\u63d0\u53d6\u72690504\u53ef\u4ee5\u963b\u65adHIV\u75c5\u6bd2\u4f20\u64ad\uff0c\u5728HIV\u5165\u4fb5\u5bbf\u4e3b\u7ec6\u80de\u65f6\uff0c0504\u80fd\u591f\u6291\u5236HIV\u4e0e\u7ec6\u80de\u878d\u5408\uff0c\u5728\u878d\u5408\u9636\u6bb5\u4fdd\u62a4\u673a\u4f53\u514d\u53d7\u5165\u4fb5\uff1b\u540c\u6837\u5e38\u89c1\u7684\u8336\u53f6\u4e5f\u662f\u56e0\u6b64\u673a\u5236\u4f5c\u4e3aHIV\u963b\u65ad\u5242\uff0c\u8336\u53f6\u4e2d\u8336\u591a\u915a\u4e5f\u80fd\u6291\u5236HIV\u4e0e\u7ec6\u80de\u878d\u5408\uff0c\u7279\u5f02\u6027\u5730\u4f5c\u7528\u4e8egp41\u3002<\/p>\n<p>\u4e8c\u3001\u5e72\u6270\u75c5\u6bd2RNA\u5411DNA\u7684\u8f6c\u5f55\u8fc7\u7a0b<br \/>\nHIV\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u7ed3\u5408\u540e\uff0c\u8fdb\u5165\u7ec6\u80de\u8d28\u7684\u75c5\u6bd2\u6838\u8863\u58f3\u5f00\u59cb\u8131\u58f3\uff0c\u88ab\u91ca\u653e\u51fa\u7684RNA\u901a\u8fc7\u9006\u8f6c\u5f55\u9176\u4ea7\u751f\u8d1f\u94feDNA\uff0c\u5728RNA\u9176H\u7684\u4f5c\u7528\u4e0b\uff0c\u4e2d\u95f4\u4f53\u4eb2\u4ee3\u7684RNA\u94fe\u88ab\u6c34\u89e3\uff0c\u7136\u540e\u4ee5\u8d1f\u94feDNA\u4f5c\u4e3a\u6a21\u7248\uff0c\u5f62\u6210\u6b63\u94feDNA\uff0c\u5408\u6210\u7684\u53cc\u94fe\u75c5\u6bd2DNA\u5373\u75c5\u6bd2cDNA\uff0c\u6b64\u65f6\u57fa\u56e0\u7ec4\u5e8f\u5217\u7531\u5bbf\u4e3b\u7ec6\u80de\u8d28\u79fb\u884c\u81f3\u7ec6\u80de\u6838\u3002\u9006\u8f6c\u5f55\u9176\u6291\u5236\u5242\u5c31\u662f\u4f5c\u7528\u4e8e\u6b64\u9636\u6bb5\uff0c\u6291\u5236HIV\u75c5\u6bd2RNA\u9006\u8f6c\u5f55\u6210DNA\uff0c\u963b\u65ad\u75c5\u6bd2\u7684\u8fdb\u4e00\u6b65\u5165\u4fb5\uff0c\u5728\u9006\u8f6c\u5f55\u8fc7\u7a0b\u4e2d\u8d77\u5230\u4e86\u963b\u65ad\u5242\u7684\u4f5c\u7528\u3002\u5176\u5728\u4e0eHIV-1\u4f5c\u7528\u540e\u4f1a\u5feb\u901f\u5f15\u53d1\u9006\u8f6c\u5f55\u9176\u7684\u4f5c\u7528\u4f4d\u70b9\u8868\u9762\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u6216\u8005\u591a\u70b9\u5728\u540c\u4e00\u65f6\u95f4\u7a81\u53d8\uff0c\u7531\u6b64\u4ea7\u751f\u8010\u836f\u6027\u3002<\/p>\n<p>\u4e09\u3001\u963b\u65ad\u75c5\u6bd2\u5728\u5bbf\u4e3b\u7ec6\u80de\u5185\u590d\u5236<br \/>\nHIV\u75c5\u6bd2\u5b8c\u6210\u9006\u8f6c\u5f55\u4e4b\u540e\u8fdb\u5165\u6574\u5408\u9636\u6bb5\uff0c\u53cc\u94feDNA\u643a\u5e26HIV\u75c5\u6bd2\u7684\u9057\u4f20\u7269\u8d28\u88ab\u8f6c\u8fd0\u5230\u5bbf\u4e3b\u7ec6\u80de\u7684\u7ec6\u80de\u6838\u5185\uff0cHIV\u75c5\u6bd2\u5f00\u59cb\u5728\u5bbf\u4e3b\u7ec6\u80de\u5185\u8fdb\u884c\u590d\u5236\uff0c\u6574\u5408\u9176\u6291\u5236\u5242\u548c\u86cb\u767d\u9176\u6291\u5236\u5242\u5728\u6b64\u9636\u6bb5\u53d1\u6325\u4f5c\u7528\uff0c\u6291\u5236\u75c5\u6bd2\u5728\u5bbf\u4e3b\u7ec6\u80de\u4e2d\u590d\u5236\u3002<\/p>\n<p>\uff081\uff09\u6574\u5408\u9176\u6291\u5236\u5242<br \/>\n\u5728HIV\u75c5\u6bd2\u590d\u5236\u9636\u6bb5\u4e2d\uff0c\u6574\u5408\u9176IN\u7684\u4f5c\u7528\u81f3\u5173\u91cd\u8981\u3002\u5728IN\u7684\u6574\u5408\u4e0b\uff0cHIV\u75c5\u6bd2\u7684DNA\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u7684DNA\u7ed3\u5408\uff0c\u6574\u5408\u7684\u8fc7\u7a0b\u4e3b\u8981\u5305\u62ec\u4e24\u4e2a\u6b65\u9aa4\uff1a\u52a0\u5de5\u548c\u94fe\u8f6c\u79fb\u3002\u6574\u5408\u9176\u6291\u5236\u5242\u662f\u5728\u94fe\u8f6c\u79fb\u7684\u8fc7\u7a0b\u4e2d\u7ecf\u50ac\u5316\u5f62\u6210\u7684\u87af\u5408\u7269\uff0c\u6291\u5236HIV\u75c5\u6bd2DNA\u4e0e\u5bbf\u4e3b\u7ec6\u80deDNA\u7ed3\u5408\u3002\u7531\u4e8e\u4eba\u4f53\u4e2d\u4e0d\u5b58\u5728IN\u7684\u540c\u6e90\u86cb\u767d\uff0c\u56e0\u6b64\uff0c\u4ee5IN\u4e3a\u9776\u6807\u7684\u6bd2\u526f\u4f5c\u7528\u76f8\u5bf9\u8f83\u5c0f\u3002\u76ee\u524d\u7684\u6574\u5408\u9176\u6291\u5236\u5242\u6709\u5f88\u591a\u79cd\uff0c\u5982\u62c9\u66ff\u62c9\u97e6\uff08\u5176\u7f3a\u70b9\u662f\u76f8\u6bd4\u5176\u5b83\u836f\u7269\u670d\u7528\u6b21\u6570\u8f83\u591a\uff09\u3001\u591a\u66ff\u62c9\u97e6\uff08\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u548c\u4f53\u91cd\u9ad8\u4e8e40kg\u7684\u513f\u7ae5\u3001\u9752\u5c11\u5e74\u60a3\u8005\uff09\u3001\u57c3\u66ff\u683c\u97e6\uff08\u5408\u6210\u8f83\u590d\u6742\uff09\u4ee5\u53ca\u827e\u7ef4\u96f7\u97e6\u7b49\u3002\u81ea\u7136\u7269\u8d28\u6b21\u76d8\u5b62\u5c5e\u83cc\u682a\uff0c\u662f\u690d\u7269\u4ea7\u751f\u7684\u771f\u83cc\uff0c\u5176\u4ee3\u8c22\u4ea7\u7269AME\u4e5f\u80fd\u591f\u7279\u5f02\u6027\u5730\u963b\u65adHIV-1\u6574\u5408\u9176\u3002<\/p>\n<p>\uff082\uff09\u86cb\u767d\u9176\u6291\u5236\u5242<br \/>\n\u86cb\u767d\u9176\u662f\u753199\u4e2a\u6c28\u57fa\u9178\u6784\u6210\u7684\u80bd\u94fe\uff0c\u86cb\u767d\u9176\u80fd\u591f\u52a0\u5de5HIV-1\u611f\u67d3\u5230\u5bbf\u4e3b\u7ec6\u80de\u7684\u6210\u719f\u75c5\u6bd2\u9897\u7c92\uff0c\u6291\u5236\u86cb\u767d\u9176\u5c31\u53ef\u4ee5\u6291\u5236HIV\u7684\u8fdb\u4e00\u6b65\u611f\u67d3\uff0c\u6240\u4ee5\u7814\u53d1\u86cb\u767d\u9176\u6291\u5236\u5242\u53ef\u4f5c\u4e3a\u653b\u7834\u827e\u6ecb\u75c5\u4f20\u67d3\u7684\u4e00\u4e2a\u65b9\u5411\u3002PIs\u7684\u4f5c\u7528\u673a\u7406\u662f\u6a21\u62df\u80bd\u94fe\u4e0e\u86cb\u767d\u9176\u7ed3\u5408\uff0c\u4f7fHIV-1\u5728\u5bbf\u4e3b\u7ec6\u80de\u4e2d\u4ea7\u751f\u4e86\u5e7c\u7a1a\u7684\u4e14\u4e0d\u5177\u611f\u67d3\u6027\u7684HIV\u75c5\u6bd2\u9897\u7c92\uff0c\u6291\u5236\u4e86\u75c5\u6bd2\u672c\u8eab\u7684\u4f5c\u7528\uff0c\u963b\u65adHIV\u75c5\u6bd2\u7684\u4f20\u64ad\u3002\u4e00\u4e9b\u7075\u957f\u7c7b\u52a8\u7269\u5982\u6052\u6cb3\u7334\u548c\u975e\u6d32\u7eff\u7334\u7684\u4f53\u7ec6\u80de\u53ef\u4ee5\u4ea7\u751f\u4e00\u79cdTRIM5-\u03b1\u86cb\u767d\uff0c\u8fd9\u79cd\u7279\u6b8a\u7684\u86cb\u767d\u5c31\u662f\u80fd\u591f\u5e72\u6270HIV\u75c5\u6bd2\u7684\u6b63\u5e38\u590d\u5236\u9014\u5f84\uff0c\u4f7fHIV\u4e0d\u80fd\u4efb\u610f\u590d\u5236\u3001\u611f\u67d3\uff0c\u9650\u5236\u548c\u963b\u788d\u4e86HIV\u611f\u67d3\u7684\u80fd\u529b\u3002<\/p>\n<p>\u56db\u3001\u4ea7\u751f\u6dcb\u5df4\u7ec6\u80de\u62b5\u5fa1HIV<br \/>\n\u9664\u8fdb\u884cHIV\u75c5\u6bd2\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u9636\u6bb5\u7684\u963b\u65ad\uff0c\u6291\u5236\u8fc7\u7a0b\u4e5f\u53ef\u4ee5\u53d1\u751f\u5728HIV\u672a\u4fb5\u5165\u7ec6\u80de\u65f6\uff0c\u5982\u5916\u6e90\u6027\u7ec6\u80de\u56e0\u5b50IL-15\u80fd\u591f\u4fc3\u8fdbT\u6dcb\u5df4\u7ec6\u80de\u7684\u6d3b\u5316\u589e\u6b96\uff0c\u5177\u6709\u514d\u75ab\u6b63\u5411\u8c03\u8282\u4f5c\u7528\uff0c\u589e\u5f3a\u4e86\u514d\u75ab\u7cfb\u7edf\u7684\u514d\u75ab\u529f\u80fd\uff0c\u62b5\u5fa1HIV\u75c5\u6bd2\u5165\u4fb5\u3002\u836f\u7269\u8fbe\u82a6\u90a3\u97e6\u80fd\u591f\u6709\u6548\u3001\u9488\u5bf9\u6027\u7684\u963b\u6b62\u6210\u719f\u75c5\u6bd2\u7ec6\u80de\u7c92\u5b50\u7684\u4ea7\u751f\uff0c\u4e0e\u5176\u4ed6\u6297\u827e\u6ecb\u75c5\u836f\u7269\u8054\u5408\u4f7f\u7528\u53ef\u4ee5\u964d\u4f4e\u8840\u6db2\u4e2dHIV\u542b\u91cf\uff0c\u589e\u52a0CD4+\u7ec6\u80de\u6570\u91cf\uff0c\u63d0\u9ad8\u60a3\u8005\u7684\u514d\u75ab\u529f\u80fd\u3002\u8fd9\u4e9b\u963b\u65ad\u5242\u5229\u7528\u6b64\u79cd\u673a\u5236\u80fd\u5728\u75c5\u6bd2\u653b\u51fb\u524d\u5c31\u8fdb\u884c\u81ea\u6211\u9884\u9632\uff0c\u800c\u662f\u4e00\u79cd\u6709\u6548\u4e14\u91cd\u8981\u7684\u9014\u5f84\u3002<\/p>\n<p>\u6211\u56fd\u827e\u6ecb\u75c5\u6d41\u884c\u8d8b\u52bf\u5341\u5206\u4e25\u5cfb\uff0c\u9632\u6cbb\u5de5\u4f5c\u523b\u4e0d\u5bb9\u7f13\u3002\u73b0\u5728\u5df2\u6709\u5927\u91cfHIV\u963b\u65ad\u5242\u88ab\u7814\u53d1\uff0c\u8fd9\u4e9b\u963b\u65ad\u5242\u5728HIV\u75c5\u6bd2\u611f\u67d3\u8fc7\u7a0b\u4e2d\u4ece\u591a\u4e2a\u9636\u6bb5\u8fdb\u884c\u7a81\u7834\uff0c\u5145\u5206\u5229\u7528\u5176\u611f\u67d3\u673a\u5236\uff0c\u6709\u6548\u5730\u963b\u65adHIV\u3002\u7efc\u4e0a\u6240\u8ff0\uff0cHIV\u963b\u65ad\u5242\u7684\u51fa\u73b0\u4f7f\u827e\u6ecb\u75c5\u7684\u6cbb\u7597\u524d\u666f\u53d8\u5f97\u5149\u660e\uff0c\u4e4b\u524d\u5b58\u5728\u7684\u4e0d\u53ef\u653b\u7834\u7684\u95ee\u9898\u6b63\u5728\u9010\u6e10\u88ab\u89e3\u51b3\u3002\u76ee\u524d\u7684\u836f\u7269\u4e0d\u80fd\u591f\u76f4\u63a5\u7684\u6d88\u706d\u75c5\u6bd2\uff0c\u53ea\u80fd\u662f\u963b\u65ad\u75c5\u6bd2\u7684\u611f\u67d3\u3002\u73b0\u5982\u4eca\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u628a\u76ee\u5149\u6295\u5411\u5f00\u53d1\u5f7b\u5e95\u6e05\u9664\u4f53\u5185HIV\u75c5\u6bd2\u7684\u836f\u7269\uff0c\u4eba\u7c7b\u7684\u76ee\u7684\u5df2\u7ecf\u4e0d\u4ec5\u4ec5\u662f\u60f3\u8981\u63a7\u5236\u827e\u6ecb\u75c5\uff0c\u800c\u662f\u6cbb\u6108\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54ea\u91cc\u8d2d\u4e70\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u4ef7\u683c\uff0c\u827e\u6ecb\u75c5\u963b\u65ad\u836f\u54c1\u9500\u552e\u673a\u6784\uff1f","protected":false},"author":1,"featured_media":1105,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3,57],"tags":[323,322,321,55],"_links":{"self":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/1104"}],"collection":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1104"}],"version-history":[{"count":1,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/1104\/revisions"}],"predecessor-version":[{"id":1106,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/posts\/1104\/revisions\/1106"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=\/wp\/v2\/media\/1105"}],"wp:attachment":[{"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1104"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/baijianyy.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}